Pharmacokinetics in Organ Failure — DCE Clinical Case

DCE long-case clinical station: comprehensive medication review and dose adjustment in organ failure in a complex elderly patient with CKD, atrial fibrillation, diabetes and polypharmacy — structured problem list, renal and hepatic dosing, therapeutic drug monitoring, and the Beers/STOPP-START framework.

Prompt

Pharmacokinetics in Organ Failure — Clinical Case

References9Show

[1]Cockcroft DW, Gault MH Prediction of creatinine clearance from serum creatinine Nephron, 1976.PMID 1244564
[2]Inker LA, Eneanya ND, Coresh J, et al. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race N Engl J Med, 2021.PMID 34554658
[3]Rybak MJ, Le J, Lodise TP, et al. Therapeutic Monitoring of Vancomycin for Serious Methicillin-resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review by the American Society of Health-system Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists Clin Infect Dis, 2020.PMID 32658968
[4]2023 American Geriatrics Society Beers Criteria Update Expert Panel American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults J Am Geriatr Soc, 2023.PMID 37139824
[5]O'Mahony D, et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 3 Eur Geriatr Med, 2023.PMID 37256475
[6]Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R Transection of the oesophagus for bleeding oesophageal varices Br J Surg, 1973.PMID 4541913
[7]Lapi F, Azoulay L, Yin H, Nessim SJ, Suissa S Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study BMJ, 2013.PMID 23299844
[8]FitzGerald JD, Dalbeth N, Mikuls T, et al. 2020 American College of Rheumatology Guideline for the Management of Gout Arthritis Care Res (Hoboken), 2020.PMID 32391934
[9]Akao M, Yamashita T, Suzuki S, Okumura K; J-ELD AF Investigators Clinical outcomes according to dose reduction criteria of apixaban in Japanese elderly patients with atrial fibrillation: J-ELD AF Registry subanalysis Heart Vessels, 2021.PMID 33486555

Pharmacokinetics in Organ Failure — DCE Clinical Case

References9Show

[1]Cockcroft DW, Gault MH Prediction of creatinine clearance from serum creatinine Nephron, 1976.PMID 1244564
[2]Inker LA, Eneanya ND, Coresh J, et al. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race N Engl J Med, 2021.PMID 34554658
[3]Rybak MJ, Le J, Lodise TP, et al. Therapeutic Monitoring of Vancomycin for Serious Methicillin-resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review by the American Society of Health-system Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists Clin Infect Dis, 2020.PMID 32658968
[4]2023 American Geriatrics Society Beers Criteria Update Expert Panel American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults J Am Geriatr Soc, 2023.PMID 37139824
[5]O'Mahony D, et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 3 Eur Geriatr Med, 2023.PMID 37256475
[6]Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R Transection of the oesophagus for bleeding oesophageal varices Br J Surg, 1973.PMID 4541913
[7]Lapi F, Azoulay L, Yin H, Nessim SJ, Suissa S Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study BMJ, 2013.PMID 23299844
[8]FitzGerald JD, Dalbeth N, Mikuls T, et al. 2020 American College of Rheumatology Guideline for the Management of Gout Arthritis Care Res (Hoboken), 2020.PMID 32391934
[9]Akao M, Yamashita T, Suzuki S, Okumura K; J-ELD AF Investigators Clinical outcomes according to dose reduction criteria of apixaban in Japanese elderly patients with atrial fibrillation: J-ELD AF Registry subanalysis Heart Vessels, 2021.PMID 33486555