Myelodysplastic Syndromes — Clinical Case

DCE Long Case

Patient brief

Patient: A middle-aged or older adult with multimorbidity and a presentation centred on Myelodysplastic Syndromes. ^[1]

Presenting complaint: Subacute or acute symptoms referable to Myelodysplastic Syndromes, with enough detail to force prioritisation. ^{[1] [2]}

Past history: Common cardiometabolic and organ comorbidities that interact with the plan. ^[2]

Medications: A polypharmacy list that includes at least one interaction or dosing issue. ^[2]

Examination: Key positives and critical negatives for dangerous differentials. ^[1]

Investigations: A small set of results that change management. ^{[1] [2]}

Tasks

1. Present a prioritised problem list. ^[1]
2. Defend investigations and immediate therapy. ^{[1] [2]}
3. Provide safety-net and follow-up advice. ^[2]

Model discussion points

• Working diagnosis and acuity. ^[1]
• Differentials and discriminators. ^[2]
• Treatment sequence and monitoring. ^{[1] [2] [3]}
• Multimorbidity and communication. ^[2]