Phys Clinical Cases · rheumatological
Immunological Investigation Immunoglobulins Complement Flow Cytometry — DCE Clinical Case
DCE long-case and short-case station for Immunological Investigation Immunoglobulins Complement Flow Cytometry.
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Immunological Investigation Immunoglobulins Complement Flow Cytometry — Clinical Case
DCE Long Case
Patient brief
Patient: A middle-aged or older adult with multimorbidity and a presentation centred on Immunological Investigation Immunoglobulins Complement Flow Cytometry. [5]
Presenting complaint: Subacute or acute symptoms referable to Immunological Investigation Immunoglobulins Complement Flow Cytometry, with enough detail to force prioritisation. [6]
Past history: Common cardiometabolic and organ comorbidities that interact with the plan. [7]
Medications: A polypharmacy list that includes at least one interaction or dosing issue. [8]
Examination: Key positives and critical negatives for dangerous differentials. [1]
Investigations: A small set of results that change management. [5]
Tasks
- Present a prioritised problem list. [6]
- Defend investigations and immediate therapy. [7]
- Provide safety-net and follow-up advice. [8]
Model discussion points
- Working diagnosis and acuity. [1]
- Differentials and discriminators. [5]
- Treatment sequence and monitoring. [6]
- Multimorbidity and communication. [7]
References5ShowHide
- [1]Seitz M, Villiger P [Value of laboratory diagnosis in inflammatory rheumatologic diseases] Praxis (Bern 1994), 2002.PMID 11845615
- [5]Ye S, Li D, Liu F, Lei M, et al. In vitro evaluation of the biological activities of IgG in seven Chinese intravenous immunoglobulin preparations J Pharm Biomed Anal, 2018.PMID 29413980
- [6]Barth MJ, Mavis C, Czuczman MS, Hernandez-Ilizaliturri FJ Ofatumumab Exhibits Enhanced In Vitro and In Vivo Activity Compared to Rituximab in Preclinical Models of Mantle Cell Lymphoma Clin Cancer Res, 2015.PMID 25964296
- [7]Barsalou J, Saint-Cyr C, Drouin E, Le Deist F, et al. High prevalence of primary immune deficiencies in children with autoimmune disorders Clin Exp Rheumatol, 2011.PMID 21345299
- [8]Dialynas DP, Wilde DB, Marrack P, Pierres A, et al. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity Immunol Rev, 1983.PMID 6195085