Phys Clinical Cases · dermatological
Drug Eruptions AND Severe Cutaneous Adverse Reactions — DCE Clinical Case
DCE long-case and short-case station for Drug Eruptions AND Severe Cutaneous Adverse Reactions.
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Drug Eruptions AND Severe Cutaneous Adverse Reactions — Clinical Case
DCE Long Case
Patient brief
Patient: A middle-aged or older adult with multimorbidity and a presentation centred on Drug Eruptions AND Severe Cutaneous Adverse Reactions. [1]
Presenting complaint: Subacute or acute symptoms referable to Drug Eruptions AND Severe Cutaneous Adverse Reactions, with enough detail to force prioritisation. [1] [2]
Past history: Common cardiometabolic and organ comorbidities that interact with the plan. [2]
Medications: A polypharmacy list that includes at least one interaction or dosing issue. [2]
Examination: Key positives and critical negatives for dangerous differentials. [1]
Investigations: A small set of results that change management. [1] [2]
Tasks
- Present a prioritised problem list. [1]
- Defend investigations and immediate therapy. [1] [2]
- Provide safety-net and follow-up advice. [2]
Model discussion points
- Working diagnosis and acuity. [1]
- Differentials and discriminators. [2]
- Treatment sequence and monitoring. [1] [2] [3]
- Multimorbidity and communication. [2]
You have read the opening of this clinical case. The complete unit — every section and its primary-source references — is part of the Physician Medicine fellowship atlas.
References8Show ledgerHide ledger
- [1]Takada T Antithrombotic Drug Eruptions in Dermatology Practice: Selection Bias, Clinical Phenotypes, and Diagnostic Approaches Cureus, 2026.PMID 42465709
- [2]Srisuwatchari W, Norchai P Hypersensitivity reactions associated with nutraceuticals and dietary supplements: A narrative review Asian Pac J Allergy Immunol, 2026.PMID 42437383
- [3]Mullan KA, Davies S, Teoh K, Tucker HL, et al. Immunological and molecular signatures of carbamazepine-induced maculopapular exanthema Front Immunol, 2026.PMID 42433382
- [4]Omran S, Gan SH, Teoh SL Pharmacogenomics in drug therapy: global regulatory guidelines for managing high-risk drug reactions Eur J Hum Genet, 2026.PMID 40993225
- [5]Wu PC, Chen WT, Huang IH, Chen CB, et al. Human Leukocyte Antigens and Sulfamethoxazole/Cotrimoxazole-Induced Severe Cutaneous Adverse Reactions: A Systematic Review and Meta-Analysis JAMA Dermatol, 2024.PMID 38568509
- [6]Asgarpour JMS, Lam LM, Vogel TK, Goez HR, et al. Human Leukocyte Antigen Gene Testing and Carbamazepine-Induced Toxic Epidermal Necrolysis: A Study of Pediatric Practice J Cutan Med Surg, 2021.PMID 32909461
- [7]Doan HN, Chang MC Comparative Effectiveness of Unstable Versus Stable Resistance Training on Lower Limb Strength, Mobility, and Fear of Falling in Older Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials Am J Phys Med Rehabil, 2026.PMID 42468010
- [8]Liu HW, Tsai TL Virtual Reality-assisted Physiotherapeutic Training for Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis Am J Phys Med Rehabil, 2026.PMID 42468005