Phys Clinical Cases · rheumatological
Complement Deficiencies AND Recurrent Infections — DCE Clinical Case
DCE long-case and short-case station for Complement Deficiencies AND Recurrent Infections.
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Complement Deficiencies AND Recurrent Infections — Clinical Case
DCE Long Case
Patient brief
Patient: A middle-aged or older adult with multimorbidity and a presentation centred on Complement Deficiencies AND Recurrent Infections. [1]
Presenting complaint: Subacute or acute symptoms referable to Complement Deficiencies AND Recurrent Infections, with enough detail to force prioritisation. [1] [2]
Past history: Common cardiometabolic and organ comorbidities that interact with the plan. [2]
Medications: A polypharmacy list that includes at least one interaction or dosing issue. [2]
Examination: Key positives and critical negatives for dangerous differentials. [1]
Investigations: A small set of results that change management. [1] [2]
Tasks
- Present a prioritised problem list. [1]
- Defend investigations and immediate therapy. [1] [2]
- Provide safety-net and follow-up advice. [2]
Model discussion points
- Working diagnosis and acuity. [1]
- Differentials and discriminators. [2]
- Treatment sequence and monitoring. [1] [2] [3]
- Multimorbidity and communication. [2]
References5ShowHide
- [1]Mottaghipisheh H, Jahromi AM, Mirzaei F, Meri S, et al. Homozygous C1qA Deficiency Presenting as Early-Onset Systemic Lupus Erythematosus: A Case Report With a Literature Review Case Reports Immunol, 2026.PMID 42147803
- [2]Consolini R, Maestrini G, Abu-Rumeileh S, Costagliola G The Intertwining Between Arthritis and Inborn Errors of Immunity J Clin Med, 2026.PMID 42123030
- [3]Boccon-Gibod I, Fain O, Gobert D, Debord S, et al. French protocol for the diagnosis and management of hereditary angioedema Rev Med Interne, 2025.PMID 41168057
- [4]Schejbel L, Fadnes D, Permin H, Lappegård KT, et al. Primary complement C5 deficiencies - molecular characterization and clinical review of two families Immunobiology, 2013.PMID 23743184
- [8]Donadoni M, La Cava L, Bizzi E, Popescu Janu V, et al. Hereditary Angioedema Prophylaxis Therapy: Berotralstat and Lanadelumab Safety Profile Medicina (Kaunas), 2025.PMID 41303734