Paeds Vivas · clinical-pharmacology-and-therapeutics
Weight-based dosing, body-surface area and dose calculation — branching viva
A branching viva following one child whose calculated dose is questioned at the bedside, through the measurement of an accurate weight and height, the choice between weight-based and body-surface-area dosing, the Mosteller formula worked aloud, the application of the maximum adult-dose cap, the leading-zero and no-trailing-zero writing rules, the independent double check, and the therapeutic drug monitoring loop when the drug turns out to be a level-guided antimicrobial.
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Target exams
Stage 1 — The weight and the height
Examiner: A nine-year-old boy is admitted with a cellulitis that needs intravenous therapy. The nurse is preparing the dose and asks you to confirm it. What is the first thing you want before you prescribe, and how do you get it? [2]
Candidate target: Ask for a measured weight in kilograms on a calibrated scale, not an estimate, and record it once on the chart in kilograms. Ask for the height in centimetres as well, because some drugs are dosed by body-surface area and you may need it. State that an estimated weight is a placeholder to be replaced by a measured weight the moment a scale is available, and that the single written weight in kilograms is the foundation of every dose. [2]
Examiner probe: The scale reads 30 kg and his height is 135 cm. Why does the height matter at all? [2]
Candidate target: Because some drugs, including several antimicrobials and all cytotoxic chemotherapy, are dosed by body-surface area rather than weight, and body-surface area is calculated from both height and weight by the Mosteller formula. Having the height means you can move between the two scalars without re-measuring. [1]
References5ShowHide
- [1]El Edelbi R, Lindemalm S, Eksborg S Estimation of body surface area in various childhood ages--validation of the Mosteller formula Acta Paediatrica, 2012.PMID 22211780
- [2]Hirata KM, Kang AH, Ramirez GV, et al. Pediatric Weight Errors and Resultant Medication Dosing Errors in the Emergency Department Pediatric Emergency Care, 2019.PMID 28976456
- [3]Lesar TS Tenfold medication dose prescribing errors Annals of Pharmacotherapy, 2002.PMID 12452740
- [7]McNeil JC, Kaplan SL Vancomycin Therapeutic Drug Monitoring in Children: New Recommendations, Similar Challenges Journal of Pediatric Pharmacology and Therapeutics, 2020.PMID 32839650
- [8]Rybak MJ, Le J, Lodise TP, et al. Therapeutic Monitoring of Vancomycin for Serious Methicillin-resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review by the American Society of Health-system Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists Clinical Infectious Diseases, 2020.PMID 32658968