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Paeds Vivasinfectious-diseases

Paeds Vivas · infectious-diseases

Tuberculosis in children — branching viva

Branching viva on the exposure-infection-disease spectrum, the age-and-immunity pathophysiology, symptom-and-contact assessment, chest radiograph and Xpert MTB/RIF workup, weight-based treatment (4-month SHINE regimen for non-severe disease, 6-month for severe), tuberculosis preventive treatment, the emergency recognition of tuberculous meningitis, and notification, contact tracing and source-case finding.

branching clinical structured oral4 min readVerification in progress

Target exams

RACP General PaediatricsRACP DCEMRCPCH ClinicalRCPSC Pediatrics
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Target exams

RACP General PaediatricsRACP DCEMRCPCH ClinicalRCPSC Pediatrics
Prompt
You are the paediatric registrar in clinic. The examiner moves from classifying the child on the TB spectrum to the pathophysiology of rapid childhood progression, then to the investigation strategy, then to the treatment pathway by classification (preventive treatment, 4-month non-severe, 6-month severe), then to a tuberculous-meningitis override, and finally to notification, contact tracing and source-case finding.

Viva \u2014 Branching structured oral

Stem. A four-year-old boy is brought in thin, with a cough and intermittent fever for six weeks. His uncle was diagnosed with smear-positive pulmonary tuberculosis two weeks ago, and his chest radiograph shows right paratracheal lymph-node enlargement. [1]

Branch 1 \u2014 Classification on the spectrum

Examiner: Where does this child sit on the TB spectrum, and why does that matter? [1]

Model answer. He has TB disease, not exposure or TB infection alone, because he has both symptoms (six weeks of cough and fever with thinness) and a compatible radiograph (paratracheal lymph-node enlargement). The spectrum \u2014 exposure, TB infection (the child is well but infected), TB disease (symptoms and/or radiological signs) \u2014 matters because it dictates everything that follows: observe, treat infection, or treat disease. I classify his disease as intrathoracic, and by severity as non-severe (lymph-node, non-cavitary, smear-negative pattern). [1] [2]

Examiner follow-up: His uncle is the source case. Why is contact most useful piece of information here? [1]

Model answer. The contact history is often the most specific bedside finding in childhood TB, because it establishes recent exposure to a known infectious adult and lifts the pre-test probability of disease substantially. It also lets me obtain the source case's drug-susceptibility result, which may decide the child's empiric regimen if there is resistance, and it tells me where to direct contact tracing and source-case treatment to break the transmission chain. [1]

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References6ShowHide
  1. [1]Perez-Velez CM, Marais BJ Tuberculosis in children. N Engl J Med, 2012.PMID 22830465
  2. [2]Marais BJ, Gie RP, Schaaf HS, et al The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era. Int J Tuberc Lung Dis, 2004.PMID 15141729
  3. [5]Kay AW, González Fernández L, Takwoingi Y, et al. Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children. Cochrane Database Syst Rev, 2020.PMID 32853411
  4. [6]Seddon JA, Tugume L, Solomons R, et al The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes. Wellcome Open Res, 2019.PMID 32118118
  5. [8]Machingaidze S, Wiysonge CS, Gonzalez-Angulo Y, et al The utility of an interferon gamma release assay for diagnosis of latent tuberculosis infection and disease in children: a systematic review and meta-analysis. Pediatr Infect Dis J, 2011.PMID 21427627
  6. [7]Turkova A, Wills GH, Wobudeya E, et al. Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children. N Engl J Med, 2022.PMID 35263517
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