Paeds Vivas · pain-palliative-and-end-of-life-care
Symptom control in serious paediatric illness — branching viva
Branching viva on symptom control in serious paediatric illness: the WHO two-step ladder and weight-based morphine dosing, the breakthrough opioid fraction, safe opioid rotation and incomplete cross-tolerance, the central mechanism of opioid relief of breathlessness, antiemetic matching to the emetic pathway, terminal agitation and delirium with exclusion of reversible causes, anticholinergic choice for death rattle, the subcutaneous route and syringe driver, anticipatory prescribing for home, and proportionate palliative sedation for refractory symptoms.
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Study tools
Target exams
Opening
Examiner: A 7-year-old boy with a progressive brainstem glioma is on your ward. He is breathless, in pain, and frightened, and his parents are frightened too. Take me through how you assess and treat his symptoms. [1]
Candidate (model answer): I start with the goals of care. I sit with the parents, confirm the trajectory and what they and he are hoping for, and frame the plan around that. Then I assess each symptom. For pain I use a validated tool by age — a numeric or faces scale here, and behavioural tools (FLACC, revised-FLACC, the Paediatric Pain Profile) in the non-verbal child. For breathlessness I look at the work of breathing, the single-breath count and the anxiety, and remember the oxygen saturation measures oxygenation, not the suffering of breathing. I treat the pain and the breathlessness in parallel, and I look for reversible causes in parallel — a pleural effusion, a pneumothorax, severe anaemia — that might bend to disease-directed treatment rather than comfort opioids alone. [1] [9]
References5ShowHide
- [1]van Teunenbroek KC, Mulder RL, Ahout IML, et al A Dutch paediatric palliative care guideline: a systematic review and evidence-based recommendations for symptom treatment. BMC Palliat Care, 2024.PMID 38481215
- [2]Zernikow B, Michel E, Craig F, Anderson BJ Pediatric palliative care: use of opioids for the management of pain. Paediatr Drugs, 2009.PMID 19301934
- [9]Hui D, Bohlke K, Bao T, et al Management of Dyspnea in Advanced Cancer: ASCO Guideline. J Clin Oncol, 2021.PMID 33617290
- [5]Chen Y, Jiang J, Peng W, Zhang C Palliative sedation for children at end of life: a retrospective cohort study. BMC Palliat Care, 2022.PMID 35473555
- [11]Hugel H, Ellershaw J, Gambles M Respiratory tract secretions in the dying patient: a comparison between glycopyrronium and hyoscine hydrobromide. J Palliat Med, 2006.PMID 16629557