Paeds Vivas · rheumatology-musculoskeletal-and-sports
Reactive arthritis and post-infectious inflammatory syndromes: Viva
Branching clinical structured oral on reactive arthritis and the post-infectious inflammatory syndromes, covering the one-to-four-week latency and the trigger organisms, the HLA-B27 and the molecular mimicry, the distinction of the post-streptococcal reactive arthritis from the acute rheumatic fever with the 2015 Jones criteria, the naproxen and ibuprofen first-line treatment, the intra-articular triamcinolone hexacetonide, and the anti-tumour-necrosis-factor escalation.
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Opening question
Examiner: A nine-year-old boy limps into your emergency department with a swollen right knee and a swollen left ankle. He had a bout of bloody diarrhoea on a camping trip three weeks ago. Walk me through how you frame this problem. [4]
Candidate: My first frame is the safety frame. The acute swollen joint in a child is septic arthritis until proven otherwise, so I assess the fever, the systemic wellness, the ability to bear weight and the Kocher criteria, and I aspirate any hot joint that raises the suspicion. Once the sepsis is excluded, the second frame is the post-infectious frame. The one-to-four-week latency after the gastrointestinal infection, the asymmetric lower-limb oligoarthritis, the enthesitis at the Achilles tendon and the dactylitis of the great toe point to the reactive arthritis on the spondyloarthritis spectrum. The three-week latency after the bloody diarrhoea is the anchor. [4][9]
References6ShowHide
- [1]Ahmed S, Padhan P, Misra R Update on Post-Streptococcal Reactive Arthritis: Narrative Review of a Forgotten Disease Curr Rheumatol Rep, 2021.PMID 33569668
- [3]Gewitz MH, Baltimore RS, Tani LY, et al Revision of the Jones Criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography: a scientific statement from the American Heart Association Circulation, 2015.PMID 25908771
- [4]Zeidler H, Hudson AP Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens Curr Rheumatol Rep, 2021.PMID 34196842
- [5]Sharip A, Kunz J Understanding the Pathogenesis of Spondyloarthritis Biomolecules, 2020.PMID 33092023
- [9]Wendling D, Prati C, Chouk M Reactive Arthritis: Treatment Challenges and Future Perspectives Curr Rheumatol Rep, 2020.PMID 32458153
- [10]Stavropoulos PG, Soura E, Kanelleas A Reactive arthritis J Eur Acad Dermatol Venereol, 2015.PMID 25199646