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Paeds Vivasrheumatology-musculoskeletal-and-sports

Paeds Vivas · rheumatology-musculoskeletal-and-sports

Pain amplification, juvenile fibromyalgia and complex regional pain syndrome: Viva

Branching clinical structured oral on amplified musculoskeletal pain, juvenile fibromyalgia and complex regional pain syndrome, covering the central sensitization mechanism, the 2010 American College of Rheumatology criteria, the Budapest clinical criteria, the red flags that mandate re-investigation, and the multidisciplinary management.

branching clinical structured oral4 min readVerification in progress

Target exams

RACP DWERACP DCEMRCPCH Clinical
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Target exams

RACP DWERACP DCEMRCPCH Clinical
Prompt
A thirteen-year-old girl presents with widespread musculoskeletal pain for nine months, profound fatigue, unrefreshing sleep and three months of intermittent school attendance. Her full blood count, inflammatory markers and thyroid function are normal. The examiner asks how you classify her pain, how you exclude the inflammatory and the malignant disease, what the central sensitization mechanism is, and then how your approach would change if the pain were a severe burning regional pain in a single limb with marked allodynia and skin colour change.

This oral is built to probe the reasoning that holds the central sensitization at the centre, and to expose the candidate who has memorised the pain label without the mechanism and the red flags. The questions escalate from the classification and the exclusion to the mechanism and the management of the two main phenotypes. [7]

Opening question: the classification and the exclusion

The examiner opens with the presentation and asks how you classify her pain and what you exclude before applying the amplified pain label. [3]

A strong answer names the juvenile fibromyalgia by the 2010 American College of Rheumatology preliminary diagnostic criteria, with the Widespread Pain Index and the Symptom Severity Scale, and then the exclusion of the juvenile idiopathic arthritis, the leukaemia and the infection through the focused history, the examination and the first-line blood panel. [1][3]

Model answer. This girl has the juvenile fibromyalgia by the 2010 criteria, with the widespread pain for at least three months, the Widespread Pain Index of seven or more and the Symptom Severity Scale of five or more, and no other disorder explaining the pain. The juvenile idiopathic arthritis is excluded by the absence of the morning stiffness and the synovitis, and the leukaemia is excluded by the normal full blood count and the absence of the systemic features. The amplified pain label is applied only after the exclusion. [1][9]

Pitfall probe. What are the red flags that exclude the primary amplified pain diagnosis? The objective synovitis, the persistent fever, the weight loss, the night pain that wakes the child, the progressive neurological deficit and the cytopenias. The amplified pain label is never applied to the child with an unexplained red flag. [3][9]

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References6ShowHide
  1. [1]Ting TV, Barnett K, Lynch-Jordan A, et al. 2010 American College of Rheumatology Adult Fibromyalgia Criteria for Use in an Adolescent Female Population with Juvenile Fibromyalgia J Pediatr, 2016.PMID 26545727
  2. [3]Kashikar-Zuck S, Ting TV Juvenile fibromyalgia: current status of research and future developments Nat Rev Rheumatol, 2014.PMID 24275966
  3. [6]Eccleston C, Palermo TM, de C Williams AC, et al. Psychological therapies for the management of chronic and recurrent pain in children and adolescents Cochrane Database Syst Rev, 2012.PMID 23235601
  4. [7]Sherry DD, Sonagra M, Gmuca S The spectrum of pediatric amplified musculoskeletal pain syndrome Pediatr Rheumatol Online J, 2020.PMID 33046102
  5. [8]Dougherty BL, Zelikovsky N, Miller KS, et al. Longitudinal Impact of Parental Catastrophizing on Child Functional Disability in Pediatric Amplified Pain J Pediatr Psychol, 2021.PMID 33491076
  6. [9]Low AK, Ward K, Wines AP Pediatric complex regional pain syndrome J Pediatr Orthop, 2007.PMID 17585269
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