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Paeds Vivasclinical-pharmacology-and-therapeutics

Paeds Vivas · clinical-pharmacology-and-therapeutics

Opioids and acute pain medicines — branching viva

A branching viva following one child from post-tonsillectomy analgesia through the codeine contraindication and the CYP2D6 prodrug mechanism, on to building a safe weight-based morphine regimen, detecting opioid-induced respiratory depression early, and reversing it with naloxone.

branching clinical structured oral4 min readVerification in progress

Target exams

RACP General PaediatricsRACP DCERCPCH Progress+MRCPCH ClinicalABP General PediatricsACGME PediatricsRCPSC Pediatrics
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Study tools

Target exams

RACP General PaediatricsRACP DCERCPCH Progress+MRCPCH ClinicalABP General PediatricsACGME PediatricsRCPSC Pediatrics
Prompt
A four-year-old boy is admitted overnight after adenotonsillectomy for obstructive sleep apnoea. The examiner releases information in stages. The candidate must choose the analgesic regimen, defend the contraindication of codeine and tramadol, build a safe morphine plan with monitoring, recognise and manage opioid-induced respiratory depression, and use naloxone correctly.
Viva contract

This is a MedVellum formative branching structured oral. It is not an official RACP, RCPCH, ABP or RCPSC examination. The questions escalate in difficulty, and the model answers show the standard a candidate should reach. Practise speaking each answer aloud before revealing it. [2] [9]

Opening — choosing the regimen

Examiner: A four-year-old, 16-kilogram boy is admitted overnight after adenotonsillectomy for obstructive sleep apnoea. The on-call team has written for paracetamol, ibuprofen, and codeine. Talk me through that prescription. [1]

Model answer — openingShowHide

I would stop the codeine immediately. Codeine is contraindicated in children under 12 years and for postoperative pain after tonsillectomy or adenoidectomy in children under 18 years. [1] [2] This child sits squarely in both contraindicated groups: he is four years old and he has just had a tonsillectomy. I would replace it with a safe modern regimen — scheduled paracetamol and ibuprofen, with oral morphine or oxycodone as rescue — and because he has obstructive sleep apnoea I would monitor him overnight with continuous oximetry, use the smallest effective opioid dose, and avoid any background infusion. [6] [9]

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You have read the opening of this viva. The complete unit — every section and its primary-source references — is part of the Paediatrics Fellowship fellowship library.

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References7ShowHide
  1. [1]Racoosin JA, Roberson DW, Pacanowski MA, et al. New evidence about an old drug — risk with codeine after adenotonsillectomy New England Journal of Medicine, 2013.PMID 23614474
  2. [2]Tobias JD, Green TP, Coté CJ Codeine: Time to Say No Pediatrics, 2016.PMID 27647717
  3. [3]Dean L, Kane M Tramadol Therapy and CYP2D6 Genotype Clinical Pharmacology and Therapeutics, 2012.PMID 28520365
  4. [6]Lynn A, Nespeca MK, Bratton SL, et al. Clearance of morphine in postoperative infants during intravenous infusion: the influence of age and surgery Anesthesia and Analgesia, 1998.PMID 9585276
  5. [9]Niesters M, Overdyk F, Smith T, et al. Opioid-induced respiratory depression in paediatrics: a review of case reports British Journal of Anaesthesia, 2013.PMID 23248093
  6. [10]Sharp D, Jaffrani A A PRISMA Systematic Review on the Safety and Efficacy of Patient-Controlled Analgesia (PCA) in Pediatrics Journal of Pediatric Nursing, 2021.PMID 34139608
  7. [11]Malmros Olsson E, Lönnqvist PA, Stiller CO, et al. Rapid systemic uptake of naloxone after intranasal administration in children Paediatric Anaesthesia, 2021.PMID 33687794
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