Paeds Vivas · nephrology-urology-fluids-and-electrolytes
Nephrolithiasis and nephrocalcinosis — viva
Branching structured oral on paediatric nephrolithiasis and nephrocalcinosis, covering the lumen-versus-parenchyma distinction, hypercalciuria and the metabolic workup, the infected obstructed system as an emergency, medical expulsive therapy with tamsulosin, the surgical ladder, prevention, and medullary nephrocalcinosis from distal renal tubular acidosis.
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"This is an uncomplicated ureteric stone — an 8 mm stone at the right vesicoureteric junction with hydronephrosis but no fever and no signs of sepsis or acute kidney injury. He is stable. My immediate management is analgesia with a non-steroidal anti-inflammatory drug, an antiemetic and hydration to correct dehydration, and I screen for the red flags: fever with obstruction, a solitary kidney, and acute kidney injury, none of which he has. Because the stone is distal and under 10 mm in an afebrile child, I would start medical expulsive therapy with tamsulosin and arrange outpatient review, with urology in reserve if it fails to pass. Once it is passed or removed, I arrange a full metabolic workup — stones in children are rarely a one-off event." [1][10]
References8ShowHide
- [1]Cao B; Daniel R; McGregor R; Tasian GE Pediatric Nephrolithiasis. Healthcare (Basel), 2023.PMID 36833086
- [3]Singh P; Harris PC; Sas DJ; Lieske JC The genetics of kidney stone disease and nephrocalcinosis. Nat Rev Nephrol, 2022.PMID 34907378
- [4]Halbritter J; Baum M; Hynes AM; Rice SJ; Thwaites DT; Hildebrandt F Fourteen monogenic genes account for 15% of nephrolithiasis/nephrocalcinosis. J Am Soc Nephrol, 2015.PMID 25296721
- [5]Gefen AM; Zaritsky JJ Review of childhood genetic nephrolithiasis and nephrocalcinosis. Front Genet, 2024.PMID 38606357
- [6]Alonso-Varela M; Gil-Pena H; Santos F Incomplete distal renal tubular acidosis in children. Acta Paediatr, 2020.PMID 32212394
- [9]Soliman MG; El-Gamal O; El-Gamal S; Abdel Raheem A; Abou-Ramadan A; El-Abd A Silodosin versus Tamsulosin as Medical Expulsive Therapy for Children with Lower-Third Ureteric Stones: Prospective Randomised Study. Urol Int, 2021.PMID 33524970
- [10]Aldaqadossi HA; Shaker H; Saifelnasr M; Gaber M Efficacy and safety of tamsulosin as a medical expulsive therapy for stones in children. Arab J Urol, 2015.PMID 26413330
- [11]Medairos R; Paloian NJ; Pan A; Moyer A; Ellison JS Risk factors for subsequent stone events in pediatric nephrolithiasis: A multi-institutional analysis. J Pediatr Urol, 2022.PMID 34980558