Paeds Vivas · fetal-neonatal-and-perinatal
Neonatal hypothermia and thermoregulation — branching viva
Branching viva on why the newborn loses heat faster than it can generate it, the WHO temperature classification, the metabolic cascade of cold injury, the warm chain and plastic wrap for the very preterm, graded rewarming by severity, and kangaroo mother care.
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Prompt
A 28-week, 950 g infant arrives in the neonatal unit at 35.0 C, pale and grunting, with a bedside glucose of 1.6 mmol/L. The examiner asks: 'Why is this infant cold, how do you classify it, and what is your management?'
Branch 1 — Why the newborn is vulnerable
Examiner: "Why is this infant cold? Explain the physiology." [1]
- The newborn loses heat through four pathways: evaporation (dominant at birth while wet), radiation (skin to cooler walls, the largest in a cold cot), convection (moving air), and conduction (cold surfaces). [1]
- The newborn generates heat only by non-shivering thermogenesis in brown adipose tissue — shivering is poorly developed. [1]
- The preterm is the extreme: enormous surface-area-to-mass ratio, high transepidermal water loss through immature skin, small brown-fat and glycogen stores (laid down late in the third trimester), and an immature hypothalamus. [3]
- Thermogenesis consumes both oxygen and glucose; once glycogen is exhausted, hypoglycaemia deepens and thermogenesis fails — a vicious cycle. [9]
References6ShowHide
- [1]Aziz K Part 5: Neonatal Resuscitation 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Pediatrics, 2021.PMID 33087555
- [3]McCall EM Interventions to prevent hypothermia at birth in preterm and/or low birth weight infants. Cochrane Database Syst Rev, 2018.PMID 29431872
- [4]Abiramalatha T Delivery Room Interventions for Hypothermia in Preterm Neonates: A Systematic Review and Network Meta-analysis. JAMA Pediatr, 2021.PMID 34028513
- [6]Boundy EO Kangaroo Mother Care and Neonatal Outcomes: A Meta-analysis. Pediatrics, 2016.PMID 26702029
- [9]Hogeveen M Hypothermia and Adverse Outcomes in Very Preterm Infants: A Systematic Review. Pediatrics, 2025.PMID 40262762
- [10]Lamary M Neonatal Golden Hour: a review of current best practices and available evidence. Curr Opin Pediatr, 2023.PMID 36722754