Paeds Vivas · fetal-neonatal-and-perinatal
Neonatal anaemia, polycythaemia and thrombocytopenia: Viva
Branching clinical structured oral on the assessment and management of a pale term neonate presenting with acute anaemia in the first 24 hours of life.
On this page
Study tools
Target exams
Opening question
Describe your immediate approach to this infant. [2]
This infant has life-threatening acute anaemia with haemodynamic compromise: tachycardia, prolonged capillary refill, and desaturation. The immediate approach is airway, breathing, circulation, intravenous access, a bedside glucose, and emergency red-cell transfusion while a crossmatch proceeds. Uncrossmatched group O, D-negative blood may be used in extremis. The Transfusion of Prematures trial used 15 mL per kg in extremely low birth weight infants; that is the sourced volume, not a term-shock dose table. [2]
References4ShowHide
- [1]de Haas M Anti-D prophylaxis: past, present and future. Transfus Med, 2014.PMID 25121157
- [2]Kirpalani H Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants. N Engl J Med, 2020.PMID 33382931
- [3]Gisslen T Anemia, Iron Supplementation, and the Brain. Clin Perinatol, 2023.PMID 37866852
- [4]Krog GR Prediction of ABO hemolytic disease of the newborn using pre- and perinatal quantification of maternal anti-A/anti-B IgG titer. Pediatr Res, 2021.PMID 33173174