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Paeds Vivashaematology-oncology-and-transfusion

Paeds Vivas · haematology-oncology-and-transfusion

Lymphoma in children: Viva

Branching clinical structured oral on lymphoma in children, covering the separation of Hodgkin from non-Hodgkin lymphoma and the four high-grade paediatric non-Hodgkin subtypes, the anterior mediastinal mass as an anaesthetic emergency, the tumour lysis syndrome prophylaxis with rasburicase, the excision biopsy with flow cytometry and cytogenetics, the Ann Arbor and Murphy St Jude staging, the risk-adapted multi-agent chemotherapy, and the classic diagnostic pitfalls around the persistent node, the mediastinal mass and the rapidly growing abdominal mass.

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Prompt
A fifteen-year-old boy presents with a three-week history of a painless enlarging rubbery supraclavicular node, drenching night sweats and a six-kilogram weight loss. A chest radiograph shows a large anterior mediastinal mass. The examiner asks how you frame the problem, how you protect the airway during the diagnosis, how you stage and treat the disease, and how your approach would change for a younger child with a rapidly growing abdominal mass.

This is a branching oral built to probe the reasoning that holds the mediastinal mass and the tumour lysis syndrome at the centre, and to expose the candidate who has memorised the headline without the safety-critical corners. The questions escalate from the framing to the airway protection, the diagnosis, the staging and the definitive management, with deliberate probes into the pitfalls and the subtypes. [1]

Opening question: framing the problem

The examiner opens with the chest radiograph and the node and asks: how do you frame this problem in a single sentence, and what is your first priority? [1]

A strong answer names the classical Hodgkin lymphoma from the painless supraclavicular node, the B symptoms and the anterior mediastinal mass, and states that the first priority is the airway, because the mediastinal mass with the tracheal deviation places the boy at risk of the airway compromise under the sedation and the supine position. [8]

Model answer. This teenager has a classical Hodgkin lymphoma from the painless supraclavicular node, the B symptoms and the anterior mediastinal mass. My first priority is the airway: the boy is assessed for the stridor, the orthopnoea and the superior vena cava syndrome, kept upright, and given no sedation before the airway is secured in a controlled setting. [8]

Probe one: the airway-protective diagnosis

The examiner presses: tell me exactly how you take the biopsy of a mediastinal mass, and why. [8]

A strong answer reproduces the airway-protective principle. The excision biopsy of the supraclavicular node is taken under the local anaesthesia where possible, because it preserves the architecture and it avoids the general anaesthetic. The general anaesthetic for a mediastinal node is reserved for the airway assessed as safe by the anaesthetic, the ENT and the cardiothoracic teams together, with the rigid bronchoscope and the ECMO on standby, the spontaneous ventilation maintained and the supine position avoided. The steroids are reserved for the life-threatening obstruction, because they lyse the lymphoma and confound the biopsy. [8][9]

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References8ShowHide
  1. [1]Mauz-Körholz C, Metzger ML, Kelly KM, et al. Pediatric Hodgkin Lymphoma J Clin Oncol, 2015.PMID 26304892
  2. [2]Munir F, Hardit V, Sheikh IN Classical Hodgkin Lymphoma: From Past to Future-A Comprehensive Review of Pathophysiology and Therapeutic Advances Int J Mol Sci, 2023.PMID 37373245
  3. [3]López C, Burkhardt B, Chan JKC, et al. Burkitt lymphoma Nat Rev Dis Primers, 2022.PMID 36522349
  4. [6]Temple WC, Mueller S, Hermiston ML Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults Best Pract Res Clin Haematol, 2023.PMID 36907639
  5. [7]Lowe EJ, Woessmann W Anaplastic large cell lymphoma in children and adolescents Br J Haematol, 2025.PMID 40351161
  6. [8]Pearson JK, Tan GM Pediatric Anterior Mediastinal Mass: A Review Article Semin Cardiothorac Vasc Anesth, 2015.PMID 25814524
  7. [9]Garey CL, Laituri CA, Valusek PA Management of anterior mediastinal masses in children Eur J Pediatr Surg, 2011.PMID 21751123
  8. [10]Perissinotti AJ, Bishop MR, Bubalo J Expert consensus guidelines for the prophylaxis and management of tumor lysis syndrome in the United States: Results of a modified Delphi panel Cancer Treat Rev, 2023.PMID 37579533
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