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Paeds Vivascardiology

Paeds Vivas · cardiology

Kawasaki disease and coronary complications — branching viva

Branching viva on Kawasaki disease: the clinical criteria and incomplete disease, the ten-day IVIG and aspirin window, IVIG-resistant disease and its escalation, coronary z-score grading and anti-thrombotic management, and the long-term risk of stenosis and myocardial infarction.

branching clinical structured oral5 min readVerification in progress

Target exams

RACP DCEMRCPCH Clinical
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Target exams

RACP DCEMRCPCH Clinical
Prompt
Emergency department: an eighteen-month-old febrile, irritable child with bilateral non-purulent conjunctivitis, cracked bleeding lips, a polymorphous rash and swollen red palms, on day six of fever.

Examiner opening (Examiner)

You are the general paediatric registrar in the emergency department. An eighteen-month-old child is brought in febrile and irritable, on day six of fever, with bilateral red eyes without discharge, cracked bleeding lips, a strawberry tongue, a widespread rash, and swollen red palms and soles. Talk me through your assessment and immediate management. [1]

Exemplar opening (Candidate)

This child has a clinical picture strongly suggestive of Kawasaki disease, and because we are on day six of fever the ten-day treatment window is open but narrowing, so I will move quickly. I will confirm the fever duration and the five principal features — bilateral non-purulent conjunctivitis, oral changes, polymorphous rash, extremity changes, and cervical lymphadenopathy — and he already has four of five with the fever, which is complete Kawasaki disease. I will take blood for a full blood count, C-reactive protein, erythrocyte sedimentation rate, albumin and liver function, send a urine for microscopy, and arrange a baseline echocardiogram. While those are running I will start intravenous immunoglobulin at 2 g/kg as a single infusion over ten to twelve hours with high-dose aspirin, because treating within ten days is the single biggest factor preventing coronary aneurysms. [1]

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References6ShowHide
  1. [1]McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation, 2017.PMID 28356445
  2. [2]Newburger JW, Takahashi M, Burns JC, et al. The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med, 1986.PMID 2426590
  3. [3]Burns JC, Roberts SC, Tremoulet AH, et al. Infliximab versus second intravenous immunoglobulin for treatment of resistant Kawasaki disease in the USA (KIDCARE): a randomised, multicentre comparative effectiveness trial. Lancet Child Adolesc Health, 2021.PMID 34715057
  4. [4]Dallaire F, Dahdah N New equations and a critical appraisal of coronary artery Z scores in healthy children. J Am Soc Echocardiogr, 2011.PMID 21074965
  5. [5]Ghelani SJ, Baker AL, Friedman K, et al. Myocardial Infarction in Kawasaki Disease. J Pediatr, 2025.PMID 40368243
  6. [6]Tsuda E, Hashimoto S Changes in Coronary Aneurysm Diameters After Acute Kawasaki Disease from Infancy to Adolescence. Pediatr Cardiol, 2021.PMID 34132855
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