Paeds Vivas · endocrinology-diabetes-and-growth
Hypoglycaemia in diabetes — branching viva
Branching viva on hypoglycaemia in diabetes: recognising the confused or seizing child with type 1 diabetes as hypoglycaemic until proven otherwise, classifying severity by the ISPAD/ADA levels, explaining counter-regulatory failure and HAAF, delivering the rule of 15 and glucagon or intravenous dextrose for severe events, and preventing recurrence with continuous glucose monitoring and hybrid closed-loop therapy.
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Opening framework
My framework has three layers. First, the recognition — a confused, drowsy, or seizing child with type 1 diabetes is hypoglycaemic until proven otherwise, and I treat on suspicion without waiting for a laboratory value. Second, the physiology — the three-tier counter-regulatory defence (falling insulin, rising glucagon, rising adrenaline) fails in order in type 1 diabetes, and repeated events attenuate the adrenaline warning through hypoglycaemia-associated autonomic failure, which is the engine of recurrent severe and silent events. Third, the management — the rule of 15 for a conscious child and glucagon or intravenous dextrose for a severe event, followed by structured prevention through continuous glucose monitoring, hybrid closed-loop delivery, and two-to-three-week hypoglycaemia avoidance where awareness is impaired. [1] [2]
References8ShowHide
- [1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: Assessment and management of hypoglycemia in children and adolescents with diabetes Pediatr Diabetes, 2022.PMID 36537534
- [2]McCrimmon RJ, Sherwin RS. Hypoglycemia in type 1 diabetes Diabetes, 2010.PMID 20876723
- [3]Cryer PE. Hypoglycemia, functional brain failure, and brain death J Clin Invest, 2007.PMID 17404614
- [4]Nathan DM, Genuth S, Lachin J, et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus N Engl J Med, 1993.PMID 8366922
- [5]Tamborlane WV, Beck RW, Bode BW, et al. Continuous glucose monitoring and intensive treatment of type 1 diabetes N Engl J Med, 2008.PMID 18779236
- [8]Ly TT, Gallego PH, Davis EA, Jones TW. Impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes Diabetes Care, 2009.PMID 19587370
- [10]Jones J, James S, Brown F, et al. Dead in bed - A systematic review of overnight deaths in type 1 diabetes Diabetes Res Clin Pract, 2022.PMID 36007797
- [11]Pontiroli AE, Tagliabue E. Intranasal versus injectable glucagon for hypoglycemia in type 1 diabetes: systematic review and meta-analysis Acta Diabetol, 2020.PMID 32025860