Paeds Vivas · haematology-oncology-and-transfusion
Full blood count and blood-film interpretation in children — branching viva
Branching viva from a low haemoglobin on a printout, through age-specific interpretation, the physiological anaemia of infancy, the mean-cell-volume sort, iron dosing and the thalassaemia distinction, with a pivot to a child with isolated thrombocytopenia, an artefact, and a film that demands urgent action.
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Opening — framing the printout
The examiner begins: here is a full blood count with a haemoglobin of 100. Before I ask you anything, what is the single most important piece of information missing, and why does it change your interpretation? [1]
I would say the age of the child. A haemoglobin of 100 is read against an age-specific paediatric range, and the same number is normal for a two-month-old infant at the physiological nadir of infancy and abnormal for a ten-year-old. I cannot interpret any paediatric value without the age band, and I would not apply adult ranges. [1] [4]
References7ShowHide
- [1]Adeli K; Higgins V; Seccombe D; et al The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper. Crit Rev Clin Lab Sci, 2017.PMID 29017389
- [4]Celkan TT What does a hemogram say to us? Turk Pediatri Ars, 2020.PMID 32684755
- [6]Wang M Iron Deficiency and Other Types of Anemia in Infants and Children. Am Fam Physician, 2016.PMID 26926814
- [8]Courville EL; et al Performance of Automated Hematology Analyzer Criteria in Detecting Peripheral Blood Smear Abnormalities: A Systematic Literature Review. Int J Lab Hematol, 2026.PMID 42115681
- [9]Neunert C; Terrell DR; Arnold DM; et al American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv, 2019.PMID 31794604
- [10]Rose-Inman H; Farmen J Acute leukemia. Emerg Med Clin North Am, 2014.PMID 25060251
- [11]Lakhotia R; et al Natural history of benign ethnic neutropenia in individuals of African ancestry. Blood Cells Mol Dis, 2019.PMID 30909074