Paeds Vivas · infectious-diseases
Enteric fever and invasive bacterial enteritis — branching viva
Structured oral on the stepwise fever of enteric fever, blood-versus-stool diagnostics, XDR-aware treatment, the STEC-HUS danger, and vaccine prevention.
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Opening (2-3 minutes)
Examiner: Two children with fever and abnormal stools. Walk me through how you separate them. [1]
Strong answer: I separate invasive from non-invasive disease. The 9-year-old has a stepwise fever with relative bradycardia, constipation and abdominal pain after travel to Pakistan — that is enteric fever until proven otherwise, and I draw blood culture before antibiotics. The 4-year-old has bloody diarrhoea with little fever after a farm visit — that is Shiga-toxin producing E. coli colitis until I prove otherwise, and I send stool, watch for haemolytic uraemic syndrome, and avoid routine antibiotics. [1] [12]
References6ShowHide
- [1]Wain J, Hendriksen RS, Mikoleit ML, et al. Typhoid fever Lancet (London, England), 2015.PMID 25458731
- [4]Parry CM, Qamar FN, Rijal S, McCann N What should we be recommending for the treatment of enteric fever? Open Forum Infectious Diseases, 2023.PMID 37274536
- [5]Jin C, Gibani MM, Moore M, Juel HB, Pollard AJ Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial Lancet (London, England), 2017.PMID 28965718
- [8]Carey ME, Dyson ZA, Ingle DJ, Amir A, Baker S, Holt KE Global diversity and antimicrobial resistance of typhoid fever pathogens: insights from a meta-analysis of 13,000 Salmonella Typhi genomes eLife, 2023.PMID 37697804
- [12]Nataro JP, Kaper JB Diarrheagenic Escherichia coli Clinical Microbiology Reviews, 1998.PMID 9457432
- [13]Christopher PR, David KV, John SM, Sankarapandian V Antibiotic therapy for Shigella dysentery Cochrane Database of Systematic Reviews, 2010.PMID 20687081