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Paeds Vivasclinical-pharmacology-and-therapeutics

Paeds Vivas · clinical-pharmacology-and-therapeutics

Drug interactions and medication reconciliation — branching viva

A branching viva following one child from a new prescription through anticipating a cytochrome P450-mediated interaction, predicting the direction and timing of inhibition and induction, choosing among avoid-substitute-adjust-monitor, and reconciling every medicine at admission, transfer, and discharge.

branching clinical structured oral5 min readVerification in progress

Target exams

RACP General PaediatricsRACP DCERCPCH Progress+MRCPCH ClinicalABP General PediatricsACGME PediatricsRCPSC Pediatrics
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Target exams

RACP General PaediatricsRACP DCERCPCH Progress+MRCPCH ClinicalABP General PediatricsACGME PediatricsRCPSC Pediatrics
Prompt
A 14-year-old girl on long-term medication after liver transplantation is admitted with an infection requiring an antibiotic and antifungal. The examiner releases information in stages. The candidate must anticipate the CYP450 interaction, predict the direction and timing, choose a management strategy, and reconcile the medicines list across the admission.

Branching cross-examination

This is a MedVellum formative viva. It is not an official RACP, MRCPCH, ABP, ACGME or RCPSC station, mark scheme, duration or pass standard. Release each update only after the candidate names the interacting pair, the shared enzyme, the direction and timing of the effect, and the planned action. [1] [7]

Candidate brief

You are the general paediatric registrar caring for a 14-year-old girl who is four years post-liver-transplant. Speak as you would on a ward round. Anticipate interactions before you prescribe, name the enzyme and the direction, and reconcile every medicine at every transition. Each escalation branch leads to the next update. [7]

Paediatrics Fellowship Pro

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You have read the opening of this viva. The complete unit — every section and its primary-source references — is part of the Paediatrics Fellowship fellowship library.

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References6ShowHide
  1. [1]Li T, Hu B, Ye L, et al. Clinically Significant Cytochrome P450-Mediated Drug-Drug Interactions in Children Admitted to Intensive Care Units International journal of clinical practice, 2022.PMID 36081809
  2. [2]de Wildt SN, Kearns GL, Leeder JS, et al. Cytochrome P450 3A: ontogeny and drug disposition Clinical pharmacokinetics, 1999.PMID 10628899
  3. [4]Lu H, Rosenbaum S Developmental pharmacokinetics in pediatric populations The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2014.PMID 25762871
  4. [6]Feudtner C, Dai D, Hexem KR, et al. Prevalence of polypharmacy exposure among hospitalized children in the United States Archives of pediatrics and adolescent medicine, 2012.PMID 21893637
  5. [7]Merandi J, Sapko M, Catt C, et al. Medication Reconciliation Pediatrics in review, 2017.PMID 28044039
  6. [10]Carroll AR, Johnson JA, Stassun JC, et al. Health Literacy-Informed Communication to Reduce Discharge Medication Errors in Hospitalized Children: A Randomized Clinical Trial JAMA network open, 2024.PMID 38227315
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