Paeds Vivas · infectious-diseases
Brain abscess and intracranial suppuration — branching viva
Branching viva on recognising brain abscess and intracranial suppuration, the imaging and microbiology strategy, empiric and tailored antibiotic therapy, the aspiration-versus-excision decision, subdural empyema as a neurosurgical emergency, and the corticosteroid controversy.
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Examiner opening (Examiner)
You are the general paediatric registrar in the emergency department. A nine-year-old boy is brought in with a week of worsening frontal headache and low-grade fever, treated as sinusitis, who this morning is confused and dragging his right leg. His CT is on the screen — a 2.8 cm ring-enhancing left frontal-lobe lesion with oedema and midline shift. Talk me through your immediate assessment and plan. [1]
Exemplar opening (Candidate)
This is a febrile child with evolving focal neurology and a ring-enhancing lesion on CT — I am treating this as a suspected brain abscess, which is a neurosurgical emergency. My first priority is resuscitation and the brain. I will assess and secure his airway, breathing and circulation, treat any seizure with a benzodiazepine, and because he is drowsy with midline shift and signs of raised intracranial pressure, I will elevate the head of the bed to 30 degrees and give an osmotic agent — mannitol 0.25–0.5 g/kg IV or hypertonic 3% saline 2–5 mL/kg IV — for impending herniation. I will not perform a lumbar puncture, because a mass lesion is confirmed and it risks herniation. In parallel I will refer urgently to paediatric neurosurgery and infectious diseases, obtain a contrast MRI with gadolinium and diffusion-weighted imaging to characterise and date the lesion, take blood cultures, and arrange aspiration for pus and culture. [1] [2]
References6ShowHide
- [1]Brouwer MC, Tunkel AR, McKhann GM II, van de Beek D Brain abscess. N Engl J Med, 2014.PMID 25075836
- [2]Bodilsen J, D'Alessandris QG, Humphreys H, et al. European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults. Clin Microbiol Infect, 2024.PMID 37648062
- [3]Muzumdar D Subdural empyema in children. Childs Nerv Syst, 2018.PMID 30014307
- [4]Simjian T, Muskens IS, Lamba N, et al. Dexamethasone Administration and Mortality in Patients with Brain Abscess: A Systematic Review and Meta-Analysis. World Neurosurg, 2018.PMID 29705232
- [5]Brouwer MC, Coutinho JM, van de Beek D Clinical characteristics and outcome of brain abscess: systematic review and meta-analysis. Neurology, 2014.PMID 24477107
- [6]Brook I Brain abscess in children: microbiology and management. J Child Neurol, 1995.PMID 7594262