Paeds Vivas · rheumatology-musculoskeletal-and-sports
Bone pain and malignancy red flags — branching viva
Branching viva on paediatric bone pain and malignancy red flags: running the red-flag screen that separates benign limb pain from leukaemia, osteosarcoma, and Ewing sarcoma; applying the Jones features to distinguish leukaemia from juvenile idiopathic arthritis; reading the radiographic signatures; and enforcing the never-biopsy-outside-a-specialist-centre rule and the spinal-cord-compression emergency.
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Opening question
A six-year-old boy has three weeks of deep right thigh pain that now wakes him from sleep, he is pale and tired, and his mother has noticed a few bruises; examination shows non-articular tenderness over the distal femur. What is the clinical task at this first visit, what is the single most reliable cardinal red flag, and what two tests do you order today? [1] [2]
References5ShowHide
- [1]Cabral DA, Tucker LB. Malignancies in children who initially present with rheumatic complaints. Journal of Pediatrics, 1999.PMID 9880449
- [2]Jones OY, Spencer CH, Bowyer SL, Dent PB, Gottlieb BS, Rabinovich CE. A multicenter case-control study on predictive factors distinguishing childhood leukemia from juvenile rheumatoid arthritis. Pediatrics, 2006.PMID 16651289
- [3]Tafaghodi F, Aghighi Y, Rokni Yazdi H, Shakiba M, Adibi A. Predictive plain X-ray findings in distinguishing early stage acute lymphoblastic leukemia from juvenile idiopathic arthritis. Clinical Rheumatology, 2009.PMID 19621208
- [8]George A, Grimer R. Early symptoms of bone and soft tissue sarcomas: could they be diagnosed earlier? Annals of the Royal College of Surgeons of England, 2012.PMID 22613305
- [9]Choi EY, Gardner JM, Lucas DR, McHugh JB, Patel RM. Ewing sarcoma. Seminars in Diagnostic Pathology, 2014.PMID 24680181