Paeds Vivas · allergy-and-immunology
Allergic disease in children: integrated approach: Viva
Branching structured oral on the integrated allergic child: classifying IgE versus non-IgE disease, the shared Th2 mechanism and the atopic march, the anaphylaxis diagnosis and intramuscular-adrenaline-first rule, early-allergen-introduction prevention (LEAP/EAT/NIAID), the skin-barrier nuance (KEEP versus BEEP), and the shared decision around oral immunotherapy.
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Branch 1: Recognising the integrated problem
The candidate should recognise immediately that this is not three separate diseases but one atopic tendency expressed across skin, gut and airway. The severe early-onset eczema, the immediate reaction to egg, and the new nocturnal wheeze are the atopic march unfolding in real time, and the family atopy history confirms the genetic substrate. The single organising idea is to treat the whole child, not the presenting organ. [4]
The first priorities are to classify each manifestation by mechanism, to confirm the food allergy properly rather than on testing alone, to assess the severity and control of each organ, and to build one coordinated plan. The candidate should articulate a one-sentence problem representation: a three-year-old with multisystem atopic disease (eczema, IgE-mediated egg allergy, early asthma) following the atopic march, requiring an integrated plan and an adrenaline autoinjector pending clarification of the food allergy. [3]
References7ShowHide
- [1]Du Toit G, Roberts G, Sayre PH, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy N Engl J Med, 2015.PMID 25705822
- [2]Togias A, Cooper SF, Acebal ML, et al. Addendum guidelines for the prevention of peanut allergy in the United States: Report of the NIAID-sponsored expert panel J Allergy Clin Immunol, 2017.PMID 28065278
- [3]Sampson HA, Muñoz-Furlong A, Campbell RL, et al. Second symposium on the definition and management of anaphylaxis: summary report Ann Emerg Med, 2006.PMID 16546624
- [4]Spergel JM The atopic march: Where we are going? Can we change it? Ann Allergy Asthma Immunol, 2021.PMID 34479727
- [5]Horimukai K, Morita K, Narita M, et al. Application of moisturizer to neonates prevents development of atopic dermatitis J Allergy Clin Immunol, 2014.PMID 25282564
- [6]Bradshaw LE, Wyatt LA, Brown SJ, et al. Emollients for prevention of atopic dermatitis: 5-year findings from the BEEP randomized trial Allergy, 2023.PMID 36263451
- [7]Chu DK, Wood RA, French S, et al. Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety Lancet, 2019.PMID 31030987