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Paeds Vivasneurology-neurodisability-and-neuromuscular

Paeds Vivas · neurology-neurodisability-and-neuromuscular

Absence, focal and generalised epilepsies — branching viva

Branching viva on absence, focal and generalised epilepsies: classifying the seizure from the eyewitness account, confirming the syndrome with the EEG, choosing the syndrome-matched first-choice medicine, applying the valproate rule in a female adolescent, and recognising the drug-resistant focal epilepsy that opens the door to surgery.

branching clinical structured oral1 min readVerification in progress

Target exams

RACP DCEMRCPCH ClinicalRCPSC Pediatrics
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Study tools

Target exams

RACP DCEMRCPCH ClinicalRCPSC Pediatrics
Prompt
Outpatient clinic: a seven-year-old girl with dozens of brief staring spells a day, unresponsive during the spells, immediate recovery, no memory, normal development, and an electroencephalogram showing three-per-second generalised spike-and-wave. The examiner asks: classify the seizure, name the syndrome, give the first-choice medicine and the trial behind it — then branches to the carbamazepine-worsens-absence rule, the developmental surveillance, and finally to the same child re-presenting at fifteen with morning jerks and a generalised tonic-clonic seizure that reframes the syndrome and invokes the valproate rule.

Opening question

A seven-year-old girl has dozens of brief staring spells a day, each lasting about ten seconds, with immediate recovery and no memory of the events, and her electroencephalogram shows three-per-second generalised spike-and-wave. Classify the seizure, name the syndrome, and give the first-choice antiseizure medicine and the trial that supports it. [4] [7]

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References4ShowHide
  1. [1]Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017.PMID 28276062
  2. [2]Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017.PMID 28276060
  3. [4]Specchio N, Wirrell EC, Scheffer IE, et al. International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions. Epilepsia, 2022.PMID 35503717
  4. [7]Glauser TA, Cnaan A, Shinnar S, et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med, 2010.PMID 20200383
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