Paeds Vivas · neurology-neurodisability-and-neuromuscular
Absence, focal and generalised epilepsies — branching viva
Branching viva on absence, focal and generalised epilepsies: classifying the seizure from the eyewitness account, confirming the syndrome with the EEG, choosing the syndrome-matched first-choice medicine, applying the valproate rule in a female adolescent, and recognising the drug-resistant focal epilepsy that opens the door to surgery.
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Opening question
A seven-year-old girl has dozens of brief staring spells a day, each lasting about ten seconds, with immediate recovery and no memory of the events, and her electroencephalogram shows three-per-second generalised spike-and-wave. Classify the seizure, name the syndrome, and give the first-choice antiseizure medicine and the trial that supports it. [4] [7]
References4ShowHide
- [1]Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017.PMID 28276062
- [2]Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia, 2017.PMID 28276060
- [4]Specchio N, Wirrell EC, Scheffer IE, et al. International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions. Epilepsia, 2022.PMID 35503717
- [7]Glauser TA, Cnaan A, Shinnar S, et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med, 2010.PMID 20200383