Paeds Cases · clinical-pharmacology-and-therapeutics
Interpret and act on an out-of-range vancomycin level — OSCE
OSCE clinical-decision and communication station: interpreting an out-of-range vancomycin level in a child with serious MRSA infection, applying the area-under-the-curve target, excluding sampling and timing errors, defending the dose-adjustment plan, and explaining the plan to the nurse and family in plain language.
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You have eight minutes to manage a ward call about an out-of-range vancomycin level in a seven-year-old with a complicated MRSA bacteraemia. Use a structured approach: confirm the sample is valid, state the therapeutic target, decide whether to give the next dose, and propose a dose-adjustment and recheck plan. Then communicate the plan to the nurse and to the family in plain language. [1]
References3ShowHide
- [1]Rybak MJ, Le J, Lodise TP, et al. Therapeutic Monitoring of Vancomycin for Serious Methicillin-resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review. Clin Infect Dis, 2020.PMID 32658968
- [2]He CY, Ye PP, Liu B, et al. Population Pharmacokinetics and Dosing Optimization of Vancomycin in Infants, Children, and Adolescents with Augmented Renal Clearance. Antimicrob Agents Chemother, 2021.PMID 34339268
- [6]Jenh AM, Tamma PD, Milstone AM Extended-interval aminoglycoside dosing in pediatrics. Pediatr Infect Dis J, 2011.PMID 21407038