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Paeds Casesclinical-pharmacology-and-therapeutics

Paeds Cases · clinical-pharmacology-and-therapeutics

Interpret and act on an out-of-range vancomycin level — OSCE

OSCE clinical-decision and communication station: interpreting an out-of-range vancomycin level in a child with serious MRSA infection, applying the area-under-the-curve target, excluding sampling and timing errors, defending the dose-adjustment plan, and explaining the plan to the nurse and family in plain language.

osce clinical decision and communication3 min readVerification in progress

Target exams

MRCPCH ClinicalRACP DCERCPSC Pediatrics
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Target exams

MRCPCH ClinicalRACP DCERCPSC Pediatrics
Prompt
A seven-year-old boy on intravenous vancomycin for a complicated methicillin-resistant Staphylococcus aureus bacteraemia is 48 hours into therapy. The ward nurse calls because his trough level has returned at 9 mg/L. He has improved clinically. The nurse asks whether to give the next dose and what to do about the level. You have eight minutes to interpret the result, exclude sampling error, state the target and sampling principle, defend a dose-adjustment plan, and explain the plan to the nurse and to the family.

Candidate brief

You have eight minutes to manage a ward call about an out-of-range vancomycin level in a seven-year-old with a complicated MRSA bacteraemia. Use a structured approach: confirm the sample is valid, state the therapeutic target, decide whether to give the next dose, and propose a dose-adjustment and recheck plan. Then communicate the plan to the nurse and to the family in plain language. [1]

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References3ShowHide
  1. [1]Rybak MJ, Le J, Lodise TP, et al. Therapeutic Monitoring of Vancomycin for Serious Methicillin-resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review. Clin Infect Dis, 2020.PMID 32658968
  2. [2]He CY, Ye PP, Liu B, et al. Population Pharmacokinetics and Dosing Optimization of Vancomycin in Infants, Children, and Adolescents with Augmented Renal Clearance. Antimicrob Agents Chemother, 2021.PMID 34339268
  3. [6]Jenh AM, Tamma PD, Milstone AM Extended-interval aminoglycoside dosing in pediatrics. Pediatr Infect Dis J, 2011.PMID 21407038
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