Paeds Cases · gastroenterology-hepatology-and-nutrition
Short-bowel syndrome and intestinal failure — structured clinical encounter
Structured encounter testing the approach to a premature neonate after necrotising enterocolitis with a high-output jejunostomy and rising conjugated bilirubin: the definition and classification, the sodium principle, the trophic role of enteral feeding and glucagon-like peptide 2, the prevention of intestinal failure-associated liver disease, and a pivot to an older child on home parenteral nutrition assessed for teduglutide, serial transverse enteroplasty and transplant.
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Station 1 — recognition and classification
Asked for my first impression, I explain that a premature baby with a high-output jejunostomy after necrotising enterocolitis resection has intestinal failure from short-bowel syndrome. I would define short-bowel syndrome as the malabsorption following massive small-intestinal resection, and intestinal failure as the broader inability of the gut to sustain growth and hydration. The key prognostic feature here is the end-jejunostomy with the colon disconnected, which carries the poorest outlook of the three anatomical types, in contrast to a jejunoileal configuration with an intact colon and ileocaecal valve which would carry the best. [1]
You have read the opening of this case. The complete unit — every section and its primary-source references — is part of the Paediatrics Fellowship fellowship atlas.
References7Show ledgerHide ledger
- [1]Duggan CP; Jaksic T Pediatric Intestinal Failure. N Engl J Med, 2017.PMID 28813225
- [2]Premkumar MH Nutritional Management of Short Bowel Syndrome. Clin Perinatol, 2022.PMID 35659103
- [3]Chiba M; Arnon R; Kori M; et al Efficacy and Safety of Teduglutide in Infants and Children With Short Bowel Syndrome Dependent on Parenteral Support. J Pediatr Gastroenterol Nutr, 2023.PMID 37364133
- [5]Lee WS; Teo EH; Chong PY; Poh LK Intestinal failure-associated liver disease (IFALD): insights into pathogenesis and advances in management. Hepatol Int, 2020.PMID 32356227
- [8]Dagorno C; Breton A; Lamireau T; et al Serial Transverse Enteroplasty (STEP) for Short Bowel Syndrome (SBS) in Children: A Multicenter Study on Long-term Outcomes. J Pediatr Surg, 2025.PMID 39368852
- [10]Lee EJ; Iyer KR; Horslen S Pediatric intestinal transplantation. Semin Pediatr Surg, 2022.PMID 35725057
- [11]Crenn P; Messing B; Cynober L Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr, 2008.PMID 18440672