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Paeds Casesrespiratory-sleep-and-airway

Paeds Cases · respiratory-sleep-and-airway

Pulmonary haemorrhage and haemoptysis — clinical case

Clinical case of an infant with recurrent occult alveolar haemorrhage, iron-deficiency anaemia, and faltering growth, illustrating the exclusion-based work-up, the diagnosis of Heiner syndrome, and cause-specific management.

respiratory long case2 min readVerification in progress

Target exams

RACP DCEMRCPCH ClinicalABP General Pediatrics
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Target exams

RACP DCEMRCPCH ClinicalABP General Pediatrics
Prompt
An 11-month-old boy is referred with recurrent episodes of cough, rapid breathing, and pallor over four months, two of them accompanied by a small amount of coffee-ground vomit. He is faltering in growth, has a persistent microcytic anaemia despite iron, and a chest radiograph shows bilateral patchy infiltrates. He is formula-fed with a cow-milk-based formula.

Case summary

This infant presents with the occult face of pulmonary haemorrhage: recurrent cough and tachypnoea with pallor, an iron-deficiency anaemia that will not respond to iron, and shifting bilateral infiltrates, with only coffee-ground vomit rather than frank haemoptysis. The essential insight is that a young child swallows rather than coughs up blood, so recurrent alveolar bleeding masquerades as anaemia and breathlessness, and his cow-milk-based feeding immediately raises the possibility of a milk-driven cause. [3] [4]

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References4ShowHide
  1. [1]Arasi S, Mastrorilli C, Pecoraro L, et al Heiner Syndrome and Milk Hypersensitivity: An Updated Overview on the Current Evidence. Nutrients, 2021.PMID 34070007
  2. [2]Moissidis I, Chaidaroon D, Vichyanond P, et al Milk-induced pulmonary disease in infants (Heiner syndrome). Pediatr Allergy Immunol, 2005.PMID 16176405
  3. [3]Saha BK Idiopathic pulmonary hemosiderosis: A state of the art review. Respir Med, 2021.PMID 33246295
  4. [4]Susarla SC, Fan LL Diffuse alveolar hemorrhage syndromes in children. Curr Opin Pediatr, 2007.PMID 17505192
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