Variant of uncertain significance on prenatal microarray — structured clinical encounter

Station brief (candidate)

You are the paediatric registrar on the fetal medicine multidisciplinary round. Priya is 34 years old at 18 weeks gestation. Her mid-trimester anatomy scan showed bilateral ventriculomegaly. Amniocentesis was performed and the chromosomal microarray returned a copy-number variant classified as a variant of uncertain significance. She has Googled the finding and is frightened. She asks whether her baby will have a disability and whether she should "do something about it." You have 12 minutes with the patient and 5 minutes for examiner discussion. ^{[6] [11]}