Paeds Cases · gastroenterology-hepatology-and-nutrition
Parenteral nutrition and refeeding syndrome — structured clinical encounter
Structured encounter testing the approach to a malnourished adolescent with anorexia nervosa admitted for refeeding whose phosphate falls on day two: the definition and biochemistry of refeeding syndrome, the ASPEN risk stratification, the thiamine and conservative-calorie prevention, the daily electrolyte monitoring, and a pivot to a premature infant on long-term parenteral nutrition with a rising conjugated bilirubin assessed for the lipid strategy and the prevention of intestinal failure-associated liver disease.
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Station 1 — recognition and definition
Asked for my first impression, I explain that a malnourished adolescent with anorexia nervosa, admitted for refeeding after prolonged negligible intake and significant weight loss, is at the highest risk of refeeding syndrome. I would define refeeding syndrome as the metabolic and fluid disturbance that follows the reintroduction of carbohydrate to a starved body. The phosphate fall and the oedema on day two tell me the syndrome is already declaring itself, and I would treat this as an active metabolic emergency requiring correction of the electrolytes, slowing of the calories, and management of the fluid overload. [5]
References6ShowHide
- [1]Joosten K; Embleton N; Yan W; et al ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Energy. Clin Nutr, 2018.PMID 30078715
- [3]Mihatsch WA; Braegger C; Bronsky J; et al ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition. Clin Nutr, 2018.PMID 30471662
- [5]da Silva JSV; Seres DS; Sabino K; et al ASPEN Consensus Recommendations for Refeeding Syndrome. Nutr Clin Pract, 2020.PMID 32115791
- [6]Corsello A; Trovato CM; Dipasquale V; et al Refeeding Syndrome in Pediatric Age, An Unknown Disease: A Narrative Review. J Pediatr Gastroenterol Nutr, 2023.PMID 37705405
- [8]Lee WS; Chew KS; Ng RT; et al Intestinal failure-associated liver disease (IFALD): insights into pathogenesis and advances in management. Hepatol Int, 2020.PMID 32356227
- [9]Fundora J; Aucott SW Intestinal Failure-Associated Liver Disease in Neonates. Neoreviews, 2020.PMID 32873652