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Paeds Casesgastroenterology-hepatology-and-nutrition

Paeds Cases · gastroenterology-hepatology-and-nutrition

Parenteral nutrition and refeeding syndrome — structured clinical encounter

Structured encounter testing the approach to a malnourished adolescent with anorexia nervosa admitted for refeeding whose phosphate falls on day two: the definition and biochemistry of refeeding syndrome, the ASPEN risk stratification, the thiamine and conservative-calorie prevention, the daily electrolyte monitoring, and a pivot to a premature infant on long-term parenteral nutrition with a rising conjugated bilirubin assessed for the lipid strategy and the prevention of intestinal failure-associated liver disease.

structured clinical encounter3 min readVerification in progress

Target exams

RACP General PaediatricsRACP DCEMRCPCH ClinicalRCPSC Pediatrics
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Target exams

RACP General PaediatricsRACP DCEMRCPCH ClinicalRCPSC Pediatrics
Prompt
A 15-year-old girl with anorexia nervosa is admitted for refeeding after six weeks of negligible intake and a 15 per cent weight loss, with a body mass index of 15. On day two the phosphate has fallen and she is oedematous with a rising heart rate. You are the paediatric registrar working through the definition and biochemistry, the risk stratification, the prevention, and a later scenario of a premature infant on parenteral nutrition whose conjugated bilirubin is rising.

Station 1 — recognition and definition

Asked for my first impression, I explain that a malnourished adolescent with anorexia nervosa, admitted for refeeding after prolonged negligible intake and significant weight loss, is at the highest risk of refeeding syndrome. I would define refeeding syndrome as the metabolic and fluid disturbance that follows the reintroduction of carbohydrate to a starved body. The phosphate fall and the oedema on day two tell me the syndrome is already declaring itself, and I would treat this as an active metabolic emergency requiring correction of the electrolytes, slowing of the calories, and management of the fluid overload. [5]

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References6ShowHide
  1. [1]Joosten K; Embleton N; Yan W; et al ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Energy. Clin Nutr, 2018.PMID 30078715
  2. [3]Mihatsch WA; Braegger C; Bronsky J; et al ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition. Clin Nutr, 2018.PMID 30471662
  3. [5]da Silva JSV; Seres DS; Sabino K; et al ASPEN Consensus Recommendations for Refeeding Syndrome. Nutr Clin Pract, 2020.PMID 32115791
  4. [6]Corsello A; Trovato CM; Dipasquale V; et al Refeeding Syndrome in Pediatric Age, An Unknown Disease: A Narrative Review. J Pediatr Gastroenterol Nutr, 2023.PMID 37705405
  5. [8]Lee WS; Chew KS; Ng RT; et al Intestinal failure-associated liver disease (IFALD): insights into pathogenesis and advances in management. Hepatol Int, 2020.PMID 32356227
  6. [9]Fundora J; Aucott SW Intestinal Failure-Associated Liver Disease in Neonates. Neoreviews, 2020.PMID 32873652
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