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Paeds Casesneurology-neurodisability-and-neuromuscular

Paeds Cases · neurology-neurodisability-and-neuromuscular

Non-epileptic events and functional seizures — structured clinical encounter

Structured encounter testing the approach to a fifteen-year-old girl referred for daily spells unresponsive to two escalating antiseizure drugs: the recognition of the semiology of a functional seizure, the positive confirmation by video-electroencephalogram, the management of coexisting epilepsy, and the leadership of the explanation, supervised drug withdrawal and cognitive behavioural therapy pathway.

structured clinical encounter1 min readVerification in progress

Target exams

RACP General PaediatricsRACP DCEMRCPCH ClinicalRCPSC Pediatrics
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Target exams

RACP General PaediatricsRACP DCEMRCPCH ClinicalRCPSC Pediatrics
Prompt
A fifteen-year-old girl is referred to your general paediatric clinic for spells that began a year ago and now occur several times a week. Each attack lasts five to ten minutes: she slumps, her eyes are closed and she resists them being opened, her limbs move in a variable thrashing pattern that waxes and wanes, she groans occasionally, and within a minute of the event ending she is tearful but fully oriented with no confusion or drowsiness. She has been started on two escalating antiseizure medications over the year without any change in the frequency or pattern of the events. Her parents separated six months ago, her mother has a history of depression, and she has missed substantial schooling. She has no history of epileptic seizures. On examination she is back to baseline, with a normal neurological examination, no neurocutaneous stigmata, and a positive Hoover sign when functional weakness is suggested.

Task 1 — Recognise the functional seizure (3 minutes)

Working from the eyewitness account and the examination, explain which features confirm that these attacks are functional (dissociative) seizures rather than epileptic seizures or a physiological mimic, and state why no single feature alone is sufficient to make the diagnosis. [1]

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References12ShowHide
  1. [1]Leibetseder A; Eisermann M; LaFrance WC Jr; et al How to distinguish seizures from non-epileptic manifestations Epileptic Disord, 2020.PMID 33399092
  2. [2]Doss JL; Robinson JO; et al Psychogenic non-epileptic seizures in youth: Individual and family psychiatric characteristics Front Psychiatry, 2022.PMID 36590633
  3. [3]Gasparini S; Beghi E; Ferlazzo E; et al Management of psychogenic non-epileptic seizures: a multidisciplinary approach Eur J Neurol, 2019.PMID 30300463
  4. [4]Espay AJ; Aybek S; Carson A; et al Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders JAMA Neurol, 2018.PMID 29868890
  5. [5]Lopez MR; LaFrance WC Jr Treatment of Psychogenic Nonepileptic Seizures Curr Neurol Neurosci Rep, 2022.PMID 35674871
  6. [6]Hallett M; Aybek S; Dworetzky BA; et al Functional neurological disorder: new subtypes and shared mechanisms Lancet Neurol, 2022.PMID 35430029
  7. [7]Patel H; Blake H; Dunn D Psychogenic Nonepileptic Seizures in Children and Adolescents Indian Pediatr, 2021.PMID 33713062
  8. [8]Albert DVF; Voeller K; et al Psychogenic Nonepileptic Seizures in Children and Adolescents Semin Pediatr Neurol, 2022.PMID 35450667
  9. [9]LaFrance WC Jr; Baird GL; Barry JJ; et al Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized clinical trial JAMA Psychiatry, 2014.PMID 24989152
  10. [10]Goldstein LH; Robinson EJ; Mellers JDC; et al Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial Lancet Psychiatry, 2020.PMID 32445688
  11. [11]Spiegel D; Lewis-Fernandez R; Lanius R; et al Dissociative disorders in DSM-5 Annu Rev Clin Psychol, 2013.PMID 23394228
  12. [12]Hamed SA; Attiah FA; Fawzy M Psychogenic nonepileptic seizures in adults with epilepsy: a tertiary hospital-based study Int J Neurosci, 2020.PMID 31771384
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