Paeds Cases · fetal-neonatal-and-perinatal
Neonatal acute kidney injury — case
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Prompt
An extremely preterm infant with neonatal AKI during a NICU admission for respiratory distress and PDA.
Case summary
A 3-day-old, 26-week, 750-gram male infant is ventilated for respiratory distress syndrome and on indomethacin for a haemodynamically significant patent ductus arteriosus. His serum creatinine has risen from 0.9 mg/dL on day 1 to 1.5 mg/dL on day 3, and his urine output is 0.5 mL/kg/h. His potassium is 5.8 mmol/L. The parents are anxious about his kidney function and whether there will be long-term consequences. [1]
References5ShowHide
- [1]Jetton JG, Boohaker LJ, Sethi SK, et al. Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study. Lancet Child and Adolescent Health, 2017.PMID 29732396
- [2]Starr MC, Charlton JR, Guillet R Advances in neonatal acute kidney injury. Pediatrics, 2021.PMID 34599008
- [3]Kent AL, Charlton JR, et al Neonatal acute kidney injury: a survey of neonatologists' and nephrologists' perceptions and practice management. American Journal of Perinatology, 2018.PMID 28709164
- [4]Askenazi D, Abitbol C, Boohaker L, et al. Optimizing the AKI definition during first postnatal week using Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) cohort. Pediatric Research, 2019.PMID 30643188
- [5]Harer MW, Askenazi DJ, et al Association between early caffeine citrate administration and risk of acute kidney injury in preterm infants. JAMA Pediatrics, 2018.PMID 29610830