Paeds Cases · fetal-neonatal-and-perinatal
Fetal growth restriction and small-for-gestational-age infant — case
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Prompt
A growth-restricted term infant with early neonatal hypoglycaemia and a concerned family.
Case summary
A term male infant is born at 38 weeks to a 31-year-old primigravida whose pregnancy was complicated by pre-eclampsia. Antenatal growth scans showed the estimated fetal weight falling from the 40th to the 5th centile, with absent end-diastolic flow on the umbilical artery Doppler in the last week, prompting induction. Birthweight is 2280 g (below the 3rd centile on an INTERGROWTH-21st chart). He is wasted with a disproportionately large head, loose dry skin and a low Ponderal Index. At two hours of age he is cool and a pre-feed glucose is low after a breastfeed. [1] [3] [6]
References6ShowHide
- [1]Gordijn SJ Consensus definition of fetal growth restriction: a Delphi procedure. Ultrasound in Obstetrics & Gynecology, 2016.PMID 26909664
- [2]Villar J International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Lancet, 2014.PMID 25209487
- [3]Lees CC Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE). Ultrasound in Obstetrics & Gynecology, 2013.PMID 24078432
- [4]Crispi F Long-term cardiovascular consequences of fetal growth restriction: biology, clinical implications, and opportunities for prevention from birth. American Journal of Obstetrics and Gynecology, 2018.PMID 29422215
- [5]Victora CG, Villar J, Barros FC, et al. Anthropometric characterization of impaired fetal growth: risk factors for and prognosis of newborns with stunting or wasting. JAMA Pediatrics, 2015.PMID 26147058
- [6]McKinlay CJ Neonatal glycemia and neurodevelopmental outcomes at 2 years. New England Journal of Medicine, 2015.PMID 26465984