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Paeds Casesallergy-and-immunology

Paeds Cases · allergy-and-immunology

Egg, wheat, soy, fish and shellfish allergy: Case

Clinical long case of a school-age child with egg allergy and moderate eczema on an over-restrictive elimination diet, covering the IgE-mediated mechanism, skin-prick and specific-IgE interpretation, component-resolved diagnostics with ovomucoid, the baked-egg ladder, correction of the unnecessary multi-food elimination, an ASCIA anaphylaxis action plan and adrenaline autoinjector, and family safety-netting.

paediatric long case4 min readVerification in progress

Target exams

RACP DCEMRCPCH ClinicalRCPSC Pediatrics
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Target exams

RACP DCEMRCPCH ClinicalRCPSC Pediatrics
Prompt
A previously well 4-year-old girl is reviewed in the allergy clinic. She has moderate flexural eczema. At age 18 months she developed widespread urticaria, lip swelling and vomiting within 15 minutes of eating scrambled egg, settling over an hour. Her skin-prick test to egg white is 6 mm and her egg-white specific IgE is 12 kU/L; her ovomucoid (Gal d 1) specific IgE is low at 0.8 kU/L. Her parents removed egg, wheat, soy, fish and shellfish from her diet and from the household. She has had no reactions since, and her growth has slowed from the 50th to the 25th centile over two years. They ask whether the diet and the restrictions are still necessary.

This girl has confirmed IgE-mediated egg allergy with a favourable prognostic profile, complicated by an over-restrictive elimination diet that is now affecting her growth. Her convincing immediate reaction to egg, a skin-prick test of 6 mm and an egg-white specific IgE of 12 kU/L establish egg allergy, while her low ovomucoid (Gal d 1) specific IgE indicates heat-labile, baked-egg-tolerant allergy that is likely to resolve. The removal of wheat, soy, fish and shellfish is unjustified and is the likely cause of her growth faltering, and the central management task is to confirm egg as the sole allergen, restore the other foods, introduce baked egg, and provide a focused action plan. [1]

Clinical findings

The key findings are the atopic background of moderate flexural eczema, the reproducible immediate reaction to egg, and the concordant testing that confirms egg allergy. The low ovomucoid IgE in the face of a positive whole-egg IgE is the discriminating piece: it tells the clinician that her allergy targets the heat-labile ovalbumin rather than the heat-stable ovomucoid, which predicts baked-egg tolerance and a higher likelihood of resolution. The growth faltering from the 50th to the 25th centile is the red flag for the nutritional harm of the elimination diet and is itself a clinical finding that demands correction. [3]

The candidate should articulate the problem representation clearly: a pre-school child with eczema and confirmed but favourable-pattern egg allergy, on an unnecessary multi-food elimination diet causing growth faltering, who needs dietary restoration, a baked-egg challenge, and an action plan. This single statement tells examiner diagnosis, the prognostic subclassification, the iatrogenic problem, and the plan. [2]

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References3ShowHide
  1. [1]Sicherer SH, Sampson HA Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol, 2014.PMID 24388012
  2. [2]Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol, 2010.PMID 21134576
  3. [3]Peters RL, Koplin JJ, Gurrin LC, et al. The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study. J Allergy Clin Immunol, 2022.PMID 35597613
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