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Paeds Casesinfectious-diseases

Paeds Cases · infectious-diseases

Explaining a positive antenatal syphilis screen — OSCE

Communication and structured-discussion OSCE on explaining a positive antenatal syphilis screen in pregnancy to a woman at 30 weeks gestation, covering what the diagnosis means, why immediate benzathine penicillin treatment is needed and why it must be completed at least four weeks before delivery, the Jarisch-Herxheimer reaction, the neonatal plan at delivery, partner treatment, and how screening and treatment prevent congenital infection.

osce communication diagnosis treatment prevention4 min readVerification in progress

Target exams

MRCPCH ClinicalRACP DCERCPSC Pediatrics
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Study tools

Target exams

MRCPCH ClinicalRACP DCERCPSC Pediatrics
Prompt
A 24-year-old woman at 30 weeks gestation is found on routine antenatal screening to have a reactive syphilis serology (RPR positive, TPPA confirmed). She is well and has no symptoms. She is anxious, frightened for her baby, and worried about stigma. The candidate must explain the diagnosis, why immediate benzathine penicillin treatment is needed and why it must be completed before delivery, the expected Jarisch-Herxheimer reaction, the neonatal evaluation plan at delivery, partner treatment and screening, and how antenatal screening and treatment prevent congenital infection — in plain, reassuring, non-stigmatising language.

Candidate instructions (8-minute station)

You are the paediatric or neonatal registrar meeting a woman in the antenatal clinic. She is 24 years old and 30 weeks pregnant. Her routine antenatal blood test has come back positive for syphilis. She is well and has no symptoms, and the pregnancy has been otherwise uncomplicated. She is frightened and worried about the baby, and she is upset and anxious about the stigma of a sexually transmitted infection. [11]

Your tasks are: [6]

  1. Explain what the positive syphilis test means and what syphilis is, in plain, non-stigmatising language. [6]
  2. Explain why she needs treatment now, what the treatment is (benzathine penicillin), and why it must be completed before delivery. [6]
  3. Explain the Jarisch-Herxheimer reaction she may experience after treatment, so she is not frightened by it. [13]
  4. Explain the plan for checking the baby after birth, partner testing and treatment, and how this is all preventable. [11]

You are not expected to manage her penicillin allergy yourself — flag that, if she reports one, the maternity team will arrange a safe alternative path. Use a trained interpreter if needed. [6]

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References4ShowHide
  1. [1]Gomez GB; Kamb ML; Newman LM; Mark J; Broutet N; Hawkes SJ Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis. Bull World Health Organ, 2013.PMID 23476094
  2. [6]Workowski KA; Bachmann LH; Chan PA; et al Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep, 2021.PMID 34292926
  3. [11]Desjardins AA; Saxinger L; Robinson JL Syphilis in pregnancy: A practical guide for prenatal care providers. Int J Gynaecol Obstet, 2025.PMID 40977496
  4. [13]Wendel GD Jr; Stark BJ; Jamison RB; Molina RD; Sullivan TJ Penicillin allergy and desensitization in serious infections during pregnancy. N Engl J Med, 1985.PMID 3921835
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