Paeds Cases · gastroenterology-hepatology-and-nutrition
Coeliac disease — structured clinical encounter
Structured encounter testing the approach to a fourteen-year-old with iron-deficiency anaemia refractory to oral iron, short stature and a family history of coeliac disease: recognising the non-classic presentation, the immunoglobulin A anti-tissue-transglutaminase-first workup with total immunoglobulin A, the ESPGHAN 2020 no-biopsy pathway, the gluten-on-board rule, and the management and counselling plan.
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Station brief (candidate)
You are the paediatric registrar in a general paediatric clinic. A fourteen-year-old is referred with tiredness and pallor. Her full blood count shows a microcytic anaemia with a haemoglobin of ninety-two grams per litre that has not corrected despite three months of oral iron. She has fallen from the fiftieth to the ninth centile for height, has intermittent abdominal bloating, and her maternal aunt has coeliac disease. She eats a normal gluten-containing diet. The team asks you to establish the differential and the workup, to explain a diagnostic rule, to state whether a biopsy can be avoided, and then to proceed to the management and family counselling. You have twelve minutes with the team and five minutes for examiner discussion. [2]
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- [1]Husby S; Koletzko S; Korponay-Szabó I; Kurppa K; Mearin ML; Ribes-Koninckx C European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020 J Pediatr Gastroenterol Nutr, 2020.PMID 31568151
- [2]Hill ID; Fasano A; Guandalini S; Hoffenberg E; Levy J; Reilly N NASPGHAN Clinical Report on the Diagnosis and Treatment of Gluten-related Disorders J Pediatr Gastroenterol Nutr, 2016.PMID 27035374
- [3]Giersiepen K; Lelgemann M; Stuhldreher N; Ronfani L; Husby S; Koletzko S Accuracy of diagnostic antibody tests for coeliac disease in children: summary of an evidence report J Pediatr Gastroenterol Nutr, 2012.PMID 22266486
- [4]Werkstetter KJ; Korponay-Szabó IR; Popp A; Villanacci V; Salemme M; Heilig G Accuracy in Diagnosis of Celiac Disease Without Biopsies in Clinical Practice Gastroenterology, 2017.PMID 28624578
- [5]Mearin ML; Agardh D; Antunes H; Al-Toma A; Auricchio R; Castillejo G ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease J Pediatr Gastroenterol Nutr, 2022.PMID 35758521