Paeds Cases · neurology-neurodisability-and-neuromuscular
Brain death, death by neurological criteria and organ donation: Case
Clinical case of a child who reaches brain death after a severe traumatic brain injury, covering the prerequisite checks and the correction of the confounders, the bedside brainstem reflex examination, the apnoea test with the PaCO2 thresholds, the two clinical evaluations separated by the observation period, and the donation after brain death pathway with the dead donor rule and the family counselling.
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This boy has a catastrophic and irreversible brain injury from the severe traumatic brain injury, and the team is right to consider the determination of brain death. The cause is known and irreversible, the imaging shows the large intracranial haemorrhage and the cerebral oedema, and the intracranial pressure could not be controlled, so the prerequisite of a devastating structural cause is met. The confounders must now be formally excluded before any neurological testing, the examination and the apnoea test performed by two clinicians, and the determination made across the two evaluations separated by the observation period. [3]
The prerequisite checks
The prerequisites are the checks that guarantee the examination will be interpretable, and each must be met before any reflex is tested. The cause is the severe traumatic brain injury, which is known, structural and irreversible, confirmed on the imaging and the course. The core temperature is 36.8 degrees Celsius, which is at least 36 degrees Celsius, so the hypothermia confounder is excluded. The systolic blood pressure is 95 mmHg on low-dose adrenaline, which is normal for a 5-year-old, so the hypotension confounder is excluded. The sedation has been off for over 24 hours, the drug screen is sent, the barbiturate level is confirmed therapeutic-zero, the electrolytes and the blood gas are corrected to the normal range, and a train of four confirms the full neuromuscular recovery. [1]
References6ShowHide
- [1]Wijdicks EF, Varelas PN, Gronseth GS, et al Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 2010.PMID 20530327
- [2]Nakagawa TA, Ashwal S, Mathur M, et al Clinical report—Guidelines for the determination of brain death in infants and children: an update of the 1987 task force recommendations. Pediatrics, 2011.PMID 21873704
- [3]Greer DM, Kirschen MP, Lewis A, et al Pediatric and Adult Brain Death/Death by Neurologic Criteria Consensus Guideline. Neurology, 2023.PMID 37821233
- [4]Greer DM, Shemie SD, Lewis A, et al Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project. JAMA, 2020.PMID 32761206
- [9]Weiss MJ, Hornby L, Rochwerg B, et al Canadian Guidelines for Controlled Pediatric Donation After Circulatory Determination of Death-Summary Report. Pediatr Crit Care Med, 2017.PMID 28925929
- [10]Shemie SD, Doig C, Dickens B, et al Severe brain injury to neurological determination of death: Canadian forum recommendations. CMAJ, 2006.PMID 16534069