Skip to main content
MedVellum
QuestionsVideosPricing

MedVellum

Fellowship exam preparation across every specialty: source-verified topics, questions in every format, and videos.

Product

  • Specialties
  • Questions
  • Videos
  • Exam tools
  • Pricing

Verification & policy

  • Verified register
  • Editorial policy
  • Privacy
  • Terms

Account

  • Sign in
  • Create account
  • Dashboard
  • Account & billing

© 2026 MedVellum. For education only — not a substitute for clinical judgement.

llms.txtPsychiatry LLM catalogSitemap

Paeds Casesneurology-neurodisability-and-neuromuscular

Paeds Cases · neurology-neurodisability-and-neuromuscular

Brain death, death by neurological criteria and organ donation: Case

Clinical case of a child who reaches brain death after a severe traumatic brain injury, covering the prerequisite checks and the correction of the confounders, the bedside brainstem reflex examination, the apnoea test with the PaCO2 thresholds, the two clinical evaluations separated by the observation period, and the donation after brain death pathway with the dead donor rule and the family counselling.

paediatric intensive care long case4 min readVerification in progress

Target exams

RACP DCEMRCPCH ClinicalRCPSC Pediatrics
On this page
Study tools

Target exams

RACP DCEMRCPCH ClinicalRCPSC Pediatrics
Prompt
A 5-year-old boy is ventilated in the paediatric intensive care unit after a high-speed motor vehicle crash. He has a severe traumatic brain injury with a large intracranial haemorrhage and cerebral oedema, and his intracranial pressure could not be controlled. He is in a deep coma with a Glasgow Coma Scale of 3, his pupils are 6 millimetres and fixed bilaterally, his core temperature is 36.8 degrees Celsius, his systolic blood pressure is 95 mmHg on low-dose adrenaline, and his sedation was weaned off over 24 hours ago. The team is considering the determination of brain death and the family has asked what this means.

This boy has a catastrophic and irreversible brain injury from the severe traumatic brain injury, and the team is right to consider the determination of brain death. The cause is known and irreversible, the imaging shows the large intracranial haemorrhage and the cerebral oedema, and the intracranial pressure could not be controlled, so the prerequisite of a devastating structural cause is met. The confounders must now be formally excluded before any neurological testing, the examination and the apnoea test performed by two clinicians, and the determination made across the two evaluations separated by the observation period. [3]

The prerequisite checks

The prerequisites are the checks that guarantee the examination will be interpretable, and each must be met before any reflex is tested. The cause is the severe traumatic brain injury, which is known, structural and irreversible, confirmed on the imaging and the course. The core temperature is 36.8 degrees Celsius, which is at least 36 degrees Celsius, so the hypothermia confounder is excluded. The systolic blood pressure is 95 mmHg on low-dose adrenaline, which is normal for a 5-year-old, so the hypotension confounder is excluded. The sedation has been off for over 24 hours, the drug screen is sent, the barbiturate level is confirmed therapeutic-zero, the electrolytes and the blood gas are corrected to the normal range, and a train of four confirms the full neuromuscular recovery. [1]

Paediatrics Fellowship Pro

Continue reading

You have read the opening of this case. The complete unit — every section and its primary-source references — is part of the Paediatrics Fellowship fellowship library.

Sign in to continueSee pricing
References6ShowHide
  1. [1]Wijdicks EF, Varelas PN, Gronseth GS, et al Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 2010.PMID 20530327
  2. [2]Nakagawa TA, Ashwal S, Mathur M, et al Clinical report—Guidelines for the determination of brain death in infants and children: an update of the 1987 task force recommendations. Pediatrics, 2011.PMID 21873704
  3. [3]Greer DM, Kirschen MP, Lewis A, et al Pediatric and Adult Brain Death/Death by Neurologic Criteria Consensus Guideline. Neurology, 2023.PMID 37821233
  4. [4]Greer DM, Shemie SD, Lewis A, et al Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project. JAMA, 2020.PMID 32761206
  5. [9]Weiss MJ, Hornby L, Rochwerg B, et al Canadian Guidelines for Controlled Pediatric Donation After Circulatory Determination of Death-Summary Report. Pediatr Crit Care Med, 2017.PMID 28925929
  6. [10]Shemie SD, Doig C, Dickens B, et al Severe brain injury to neurological determination of death: Canadian forum recommendations. CMAJ, 2006.PMID 16534069
Paediatrics Fellowship Pro

$29/ monthor $279 / year

The complete Paediatrics Fellowship library, every exam format, one subscription.

  • Complete library for one chosen specialty
  • Timed MCQ mock exams and spaced review
  • Clinical cases & cross-table vivas
See pricingSign in
PreviousAutoimmune encephalitis: Caseneurology-neurodisability-and-neuromuscularNextCerebral vascular malformations: Caseneurology-neurodisability-and-neuromuscular