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O&G VivasEarly pregnancy care

O&G Vivas · Early pregnancy care

Confirmed tubal ectopic — structured oral station (12 minutes)

FRANZCOG oral-format station on a confirmed unruptured tubal ectopic: candidate states the diagnostic certainty, defends methotrexate selection against the predictors of failure, reproduces the day 4 and day 7 monitoring, handles failure and rupture, and counsels for the future. Scored against the eight published RANZCOG oral domains.

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FRANZCOGMRCOGABOG
Prompt
You are the gynaecology registrar. A 33-year-old woman, G2P0, attends the early pregnancy assessment service at 7 weeks by dates with right-sided pain and light bleeding. She is stable: HR 88 bpm, BP 120/76 mmHg. Transvaginal ultrasound shows an empty uterus and a right adnexal mass 2.2 cm moving separately from the ovary with a yolk sac visible within it. There is a small amount of free fluid. Serum hCG is 1800 IU/L. She is RhD positive. The examiner will ask you to confirm the diagnosis, defend your management, and then explore what happens if treatment fails.

Station format

4 minutes reading, 12 minutes examination, 20 marks, global scoring. The eight published RANZCOG oral domains apply: history and examination; investigations and interpreting results; treatment and management; clinical knowledge; complex, urgent or unusual clinical presentations; rapport with the patient, support person or colleague; respect; and communication skills. You are marked on how you behave as much as on what you know. [1]

Reveal the examiner script and model responsesShowHide

Opening prompt — "What does this scan show, and how certain are you?"

Model response — give the label, the certainty and the one qualifier. [1]

  • "This is a tubal ectopic pregnancy — diagnostic, not just probable, because there is an adnexal mass moving separately from the ovary that contains a yolk sac. A yolk sac, pole or heartbeat outside the uterus makes it diagnostic."[1]
  • "She is stable, the mass is small and her hCG is moderate, so I have time to be systematic rather than to rush her to theatre."[1]
  • "I would confirm her baseline bloods — full blood count, renal and liver function, group and antibody screen — and assess her for methotrexate, because in this stable woman medical management is my first choice."[1]

Examiner is listening for: the diagnostic (not merely probable) certainty, recognition that stability buys time, and a named plan rather than a list of possibilities. [1]

Probe 1 — "Why methotrexate rather than surgery?"

  • "She is haemodynamically stable, the ectopic is unruptured, the mass is small at 2.2 cm and her hCG is moderate. Those are the features that favour medical management."[1][2]
  • "The dominant predictor of methotrexate failure is a high presenting hCG, followed by cardiac activity and mass size. At 1800 IU/L with a small mass her chance of success is high — in the Lipscomb series single-dose methotrexate succeeded in about 90% overall."[4][3]
  • "I would exclude the contraindications first: renal or hepatic impairment, cytopenia, active peptic ulcer, pulmonary disease, breastfeeding, and any reason she could not return for follow-up."[1]

Probe 2 — "Walk me through the protocol."

  • "Single dose: methotrexate 50 mg per metre squared intramuscularly, with the day of injection as day 1. Then serum hCG on days 1, 4 and 7, and weekly after that until the hCG is negative."[1][3][8]
  • "The decision is between day 4 and day 7. A fall of 15% or more over those three days means it is working — continue weekly. Less than 15% means reassess, and usually a second dose, with another hCG on day 7 after that dose."[1][7][8]
  • "A rise between day 1 and day 4 is common and does not by itself mean failure — the comparison that matters is day 4 to day 7."[1]

Probe 3 — "Day 7 her hCG has fallen only 9% from day 4. She has new right-sided pain. What now?"

  • "Two red flags at once: an inadequate response and new pain. I reassess her now — observations, abdomen for peritonism, repeat transvaginal ultrasound looking for increasing or echogenic free fluid, and I crossmatch and involve the consultant."[1]
  • "If she is stable and the scan shows no rupture, a second dose of methotrexate is reasonable. If she becomes unstable, or the scan shows rupture, she goes to theatre — laparoscopic salpingotomy if she wants the tube spared and it is feasible, salpingectomy if the tube is badly damaged or she is unstable."[1][5]
  • "I would not keep observing a woman with new pain and a failing methotrexate course, because the failure mode is rupture."[1]

Probe 4 — "She asks you to explain it to her. She is frightened of the injection and of losing the pregnancy."

This is a scored domain. Demonstrate it in plain words. [1][6]

  • Sit down and use her name. "I know this is not the news you came for. Let me explain exactly what we have found and what I am recommending."
  • "The pregnancy is growing in your fallopian tube rather than in your womb, and a tube cannot safely hold a pregnancy. It would eventually rupture and cause dangerous bleeding, so we treat it rather than wait."
  • "A single injection of a medicine called methotrexate stops the pregnancy cells growing, and your body then absorbs them over a few weeks. Most women in your situation do not need an operation. You will need blood tests on day 4 and day 7 to check it is working, and weekly after that until the hormone is gone."
  • "You can call the unit at any time, and I want you to come straight back if you get new or one-sided pain, shoulder-tip pain, dizziness or heavy bleeding."
  • Acknowledge the loss and offer written information and support. Around three in ten women (29%) met post-traumatic stress criteria one month after an early pregnancy loss, and how this conversation goes is part of preventing that.[6]

Examiner is listening for: plain language, no jargon, a concrete monitoring plan, explicit safety-netting, and an offer of support without being asked. [6]

Probe 5 — "She asks whether she will be able to have a baby afterwards."

  • "Yes, in most cases. After an ectopic the chance of a future intrauterine pregnancy is good. If she needed surgery, the ESEP trial showed similar future pregnancy rates whether the tube is removed or preserved, provided the other tube is healthy."[5]
  • "Her risk of another ectopic is substantially raised, so in her next pregnancy I would offer her an early scan to locate the pregnancy early."[1]
  • "After methotrexate she should delay attempts to conceive for 3 months — the guideline washout period, while the manufacturer advises 6 months."[7][9]

Probe 6 — "Your colleague says methotrexate is being overused and ruptures are missed. Is that fair?"

  • "It is a fair caution. The modern pitfall is not failing to find an ectopic — it is treating a pregnancy that was never properly located, or a woman who could not comply with monitoring. Methotrexate given to a wanted intrauterine pregnancy terminates it."[1]
  • "So the safeguards are: confirm the diagnosis on ultrasound, exclude contraindications, ensure follow-up is booked before the dose is given, and safety-net for rupture even while the hCG is falling. Methotrexate is safe when it is protocolised; it is dangerous when it is casual."[1]
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References9ShowHide
  1. [1]Royal College of Obstetricians and Gynaecologists Diagnosis and Management of Ectopic Pregnancy: Green-top Guideline No. 21 BJOG, 2016.PMID 27813249
  2. [2]American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology ACOG Practice Bulletin No. 193: Tubal Ectopic Pregnancy Obstet Gynecol, 2018.PMID 29470343
  3. [3]Lipscomb GH, Bran D, McCord ML, et al. Analysis of three hundred fifteen ectopic pregnancies treated with single-dose methotrexate Am J Obstet Gynecol, 1998.PMID 9662322
  4. [4]Lipscomb GH, McCord ML, Stovall TG, et al. Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies N Engl J Med, 1999.PMID 10607814
  5. [5]Mol F, van Mello NM, Strandell A, et al. Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial Lancet, 2014.PMID 24499812
  6. [6]Farren J, Jalmbrant M, Falconieri N, et al. Posttraumatic stress, anxiety and depression following miscarriage and ectopic pregnancy: a multicenter, prospective, cohort study Am J Obstet Gynecol, 2020.PMID 31953115
  7. [7]Po L, Thomas J, Mills K, et al. Guideline No. 414: Management of Pregnancy of Unknown Location and Tubal and Nontubal Ectopic Pregnancies. J Obstet Gynaecol Can, 2021.PMID 33453378
  8. [8]Davenport MJ, Lindquist A, Brownfoot F, et al. Time to resolution of tubal ectopic pregnancy following methotrexate treatment: A retrospective cohort study. PLoS One, 2022.PMID 35609041
  9. [9]Rosh B, Hadad J, Gronich N Timing of conception after methotrexate and subsequent pregnancy outcomes: A retrospective cohort study. Int J Gynaecol Obstet, 2026.PMID 41808516
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