O&G · Sexual and reproductive health — hormonal, non-hormonal and emergency contraception
Hormonal, non-hormonal contraception and emergency contraception
Also known as Combined oral contraceptive · COC · POP · Progestin-only pill · Emergency contraception · Ulipristal acetate · Levonorgestrel EC · Copper IUD · WHO MEC
Exam-exhaustive FRANZCOG fellowship reference on the combined hormonal contraception (oestrogen plus progestin) — combined pill, patch, vaginal ring — and the progestin-only pill, plus the non-hormonal barrier, fertility awareness and emergency contraception options. WHO MEC four-tier eligibility, VTE risk, missed pills, drug interactions (enzyme inducers), ulipristal acetate vs levonorgestrel EC vs Cu-IUD for EC, dosing, timing and efficacy per option (Cochrane, Brache pooled analysis, Edelman 2024 in BMI ≥30). ANZ-primary, globally tagged to MRCOG, ABOG.
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Red flags
- Migraine with aura — combined hormonal contraception is Category 4 (do not use)
- VTE risk factors with combined oral contraceptive — oestrogen plus smoking plus age plus obesity compounds the risk
- Vomiting within 3 hours of taking the EC dose — repeat the dose
- Pregnancy with the IUD in place after failed EC — always exclude and consider ectopic
- Ulipristal acetate and rapid progestogen start — wait 5 days or use barrier
- Enzyme-inducing drugs (rifampicin, carbamazepine) and hormonal contraception — efficacy reduced, Cu-IUD unaffected
It is Saturday night. A 27-year-old nulliparous woman presents at 22:00 with a request for emergency contraception after condom breakage approximately 14 hours ago. She is on no regular contraception, has BMI 28, no migraine, no smoking, regular periods (day 12 of cycle). She wants the most effective option. You also need to plan her ongoing contraception. Across the same evening, your colleague admits a 35-year-old smoker, 2 weeks postpartum, with a VTE on admission — her combined oral contraceptive script from her GP is the precipitating factor, and the registrar on call must decide about future contraception. This topic is the script for both encounters.[6]
Overview and definition
The umbrella of "modern contraception" spans three broad families: combined hormonal contraception (oestrogen plus progestogen); progestin-only methods (pill, implant, injectables, LNG-IUS); and non-hormonal methods (Cu-IUD, barrier, fertility awareness). Each family has distinct mechanisms, eligibility, failure rates and bleeding patterns; choosing between them is the central applied skill of contraception counselling. [6][5]
- Combined hormonal contraception (CHC) contains oestrogen (ethinylestradiol in most formulations, or estradiol valerate / estradiol hemihydrate in newer formulations) plus a progestogen. Routes include the combined oral contraceptive (COC) pill, the combined transdermal patch and the combined vaginal ring. Typical-use failure rate is roughly 7 per 100 women in the first year. [6]
- Progestin-only pill (POP) contains only a progestogen — norethindrone, norgestrel or drospirenone (DRSP). Typical-use failure rate is also roughly 7 per 100 women in the first year, but the mechanism and adherence demand differ.[6]
- Emergency contraception (EC) is the use of a contraceptive method after unprotected intercourse to prevent pregnancy. Options are the copper IUD (within 5 days, most effective), ulipristal acetate 30 mg orally (within 5 days), levonorgestrel 1.5 mg orally (within 3 to 5 days, less effective in the later window and in higher BMI). [1][4]
The method-class map: combined hormonal, progestin-only, non-hormonal — the WHO MEC framework (Category 1 to 4) is the universal crosswalk between medical history and method choice. [5]
References19ShowHide
- [1]Shen J, Che Y, Showell E, Chen K, Cheng L Interventions for emergency contraception Cochrane Database Syst Rev, 2019.PMID 30661244
- [2]Brache V, Cochon L, Deniaud M, Croxatto HB Ulipristal acetate prevents ovulation more effectively than levonorgestrel: analysis of pooled data from three randomized trials of emergency contraception regimens Contraception, 2013.PMID 23809278
- [3]Edelman A, Jensen JT, Brown J, Thomas M, Archer DF, Schreiber CA, Teal S, Westhoff C, Dart C, Blithe DL Emergency contraception for individuals weighing 80 kg or greater: A randomized trial of 30 mg ulipristal acetate and 1.5 mg or 3.0 mg levonorgestrel Contraception, 2024.PMID 38663539
- [4]Glasier A Emergency contraception: clinical outcomes Contraception, 2013.PMID 23040128
- [5]Altshuler AL, Gaffield ME, Kiarie JN The WHO's medical eligibility criteria for contraceptive use: 20 years of global guidance Curr Opin Obstet Gynecol, 2015.PMID 26390246
- [6]Curtis KM, Nguyen AT, Tepper NK, Zapata LB, Snyder EM, Hatfield-Timajchy K, Kortsmit K, Cohen MA, Whiteman MK U.S. Selected Practice Recommendations for Contraceptive Use, 2024 MMWR Recomm Rep, 2024.PMID 39106301
- [7]Cleland K, Zhu H, Goldstuck N, Cheng L, Trussell J The efficacy of intrauterine devices for emergency contraception: a systematic review of 35 years of experience Hum Reprod, 2012.PMID 22570193
- [8]Turok DK, Godfrey EM, Wojdyla D, Dermish A, Torres L, Wu SC Copper T380 intrauterine device for emergency contraception: highly effective at any time in the menstrual cycle Hum Reprod, 2013.PMID 23945595
- [9]Gemzell-Danielsson K, Rabe T, Cheng L Emergency contraception Gynecol Endocrinol, 2013.PMID 23437846
- [10]Fok WK, Blumenthal PD Update on emergency contraception Curr Opin Obstet Gynecol, 2016.PMID 27676405
- [11]ESHRE Capri Workshop Group Emergency contraception. Widely available and effective but disappointing as a public health intervention: a review Hum Reprod, 2015.PMID 25678571
- [12]Bateson D, Butcher BE, Donovan C, Farrell L, Kovacs G, Mezzini T Risk of venous thromboembolism in women taking the combined oral contraceptive: A systematic review and meta-analysis Aust Fam Physician, 2016.PMID 27051991
- [13]Praditpan P, Hamouie A, Basaraba CN, Nandakumar R, Cremers S, Davis AR Pharmacokinetics of levonorgestrel and ulipristal acetate emergency contraception in women with normal and obese body mass index Contraception, 2017.PMID 28126541
- [14]Tepper NK, Curtis KM, Cox S, Whiteman MK Update to U.S. Medical Eligibility Criteria for Contraceptive Use, 2016: Updated Recommendations for the Use of Contraception Among Women at High Risk for HIV Infection MMWR Morb Mortal Wkly Rep, 2020.PMID 32271729
- [15]Sanders JN, Turok DK, Royer PA, Thompson IS, Gawron LM, Storck KE One-year continuation of copper or levonorgestrel intrauterine devices initiated at the time of emergency contraception Contraception, 2017.PMID 28596121
- [16]Fok WK, Blumenthal PD Update on emergency contraception Curr Opin Obstet Gynecol, 2016.PMID 27676405
- [17]Dragoman MV, Gaffield ME The safety of subcutaneously administered depot medroxyprogesterone acetate (104mg/0.65mL): A systematic review Contraception, 2016.PMID 26874275
- [18]Curtis KM, Nguyen AT, Tepper NK, Zapata LB, Snyder EM, Hatfield-Timajchy K, Kortsmit K, Cohen MA, Whiteman MK U.S. Selected Practice Recommendations for Contraceptive Use, 2024 MMWR Recomm Rep, 2024.PMID 39106301
- [19]Curtis KM, Tepper NK, Jatlaoui TC, Berry-Bibee E, Horton LG, Zapata LB, Simmons KB, Pagano HP, Jamieson DJ, Whiteman MK U.S. Medical Eligibility Criteria for Contraceptive Use, 2016 MMWR Recomm Rep, 2016.PMID 27467196