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O&G TopicsNeonatal care — resuscitation and transition

O&G · Neonatal care — resuscitation and transition

Neonatal resuscitation at birth

Also known as Newborn life support · NLS · Neonatal resuscitation · Delivery room resuscitation · ANZCOR newborn resuscitation · Resuscitation of the newborn

Exam-exhaustive FRANZCOG fellowship reference on neonatal resuscitation at birth — the ANZCOR newborn life support sequence with real timings, air versus oxygen and the minute-by-minute saturation targets, ventilation pressures and why ventilation fails, the 3:1 compression ratio, adrenaline dose and route, volume replacement, the deferred cord clamping interaction, and who must attend under RANZCOG C-Obs 32. ANZ-primary, globally tagged.

high20 referencesUpdated 26 July 202616 min readVerification in progress

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Practise this topic8 MCQs with explanations

Target exams

FRANZCOGMRCOGABOGFRCSCMRCPI

Red flags

  • Moving to chest compressions before the chest is visibly moving — compressions on an unaerated lung achieve nothing
  • A heart rate that will not rise despite what looks like good ventilation — reposition, reseal, suction, open the mouth, raise the pressure, consider an airway
  • The pale, floppy, unresponsive baby who does not improve with ventilation — think acute blood loss and give volume
  • Sudden deterioration after successful ventilation with a shifted apex and unequal air entry — tension pneumothorax needs a needle, not more pressure
  • Nobody in the room whose only job is the baby — C-Obs 32 makes that a system failure, not bad luck
  • Starting resuscitation in 100% oxygen at term out of habit — air first, then titrate to the saturation target
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Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

FRANZCOGMRCOGABOGFRCSCMRCPI

Red flags

  • Moving to chest compressions before the chest is visibly moving — compressions on an unaerated lung achieve nothing
  • A heart rate that will not rise despite what looks like good ventilation — reposition, reseal, suction, open the mouth, raise the pressure, consider an airway
  • The pale, floppy, unresponsive baby who does not improve with ventilation — think acute blood loss and give volume
  • Sudden deterioration after successful ventilation with a shifted apex and unequal air entry — tension pneumothorax needs a needle, not more pressure
  • Nobody in the room whose only job is the baby — C-Obs 32 makes that a system failure, not bad luck
  • Starting resuscitation in 100% oxygen at term out of habit — air first, then titrate to the saturation target
One-line fellowship answer

Newborn resuscitation is a ventilation problem wearing a cardiac-arrest costume: warm, dry and stimulate, get the airway neutral, deliver effective positive pressure ventilation in air by one minute of age, and only then escalate to chest compressions at 3:1 when the heart rate stays under 60 despite 30 seconds of chest that visibly moves — adrenaline 10 to 30 microgram/kg intravenously and volume 10 mL/kg follow, but the lungs come first.[1][2][3]

The baby is out and grey. Not crying, not moving, and the midwife is looking at you. Roughly 85% of babies breathe on their own within 30 seconds and need nothing from you at all — this one is not that baby. What separates a good registrar from a frightened one here is a sequence rehearsed until it is automatic, and the discipline to keep working on the lungs when instinct says do something dramatic.[1][2]

Overview and definition

Two words you must use precisely at the station. Newborn means the infant in the first minutes to hours after birth; the neonatal period runs to 28 days. Newborn algorithms — including the 3:1 ratio — apply to the first group, and the ANZCOR Guidelines 13.1 to 13.10 are written for them.[1][2]

Distinguish support of transition from resuscitation: [1][3]

  • Support of transition — warmth, drying, stimulation, airway position, skin-to-skin, an intact cord. This is what most babies need, and doing more is doing harm.
  • Resuscitation — positive pressure ventilation and above. Roughly 1 baby in 20 needs assisted ventilation; the number needing chest compressions or adrenaline is smaller by another order of magnitude.[2][16]

RANZCOG C-Obs 32 (Responsibility for neonatal resuscitation at birth, November 2018 with an interim update February 2023) splits the skill set the same way, and it splits the staffing with it. First-response (basic) skills cover assessment, thermal care, airway positioning, mask and supraglottic airway ventilation, chest compressions and non-technical skills. Advanced skills add intubation, vascular access including emergency umbilical venous access, drugs and fluids, and needle decompression of a pneumothorax.[1][2]

The C-Obs 32 sentence examiners want to hearAn appropriately trained practitioner, skilled in neonatal resuscitation and responsible only for the care of the newborn, should be present at every birth. At low-risk births an advanced resuscitator must be available; at high-risk births they must be in attendance — and if the facility cannot provide that, the answer is antenatal transfer, not optimism.[1][2]
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References20ShowHide
  1. [1]Liley HG, Weiner GM, Wyckoff MH, et al. Neonatal Life Support: 2025 International Liaison Committee on Resuscitation Consensus on Science With Treatment Recommendations Circulation, 2025.PMID 41122846
  2. [2]Aziz K, Lee HC, Escobedo MB, et al. Part 5: Neonatal Resuscitation: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Circulation, 2020.PMID 33081528
  3. [3]Madar J, Roehr CC, Ainsworth S, et al. European Resuscitation Council Guidelines 2021: Newborn resuscitation and support of transition of infants at birth Resuscitation, 2021.PMID 33773829
  4. [20]Resuscitation Council UK Newborn resuscitation and support of transition of infants at birth — 2025 guidelines Resuscitation Council UK, 2025.Source
  5. [4]Dawson JA, Kamlin CO, Vento M, et al. Defining the reference range for oxygen saturation for infants after birth Pediatrics, 2010.PMID 20439604
  6. [5]Dawson JA, Kamlin CO, Wong C, et al. Changes in heart rate in the first minutes after birth Arch Dis Child Fetal Neonatal Ed, 2010.PMID 20444810
  7. [6]Tan A, Schulze A, O'Donnell CP, Davis PG Air versus oxygen for resuscitation of infants at birth Cochrane Database Syst Rev, 2005.PMID 15846632
  8. [7]Davis PG, Tan A, O'Donnell CP, Schulze A Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis Lancet, 2004.PMID 15474135
  9. [8]Halling C, Sparks JE, Christie L, Wyckoff MH Efficacy of Intravenous and Endotracheal Epinephrine during Neonatal Cardiopulmonary Resuscitation in the Delivery Room J Pediatr, 2017.PMID 28285754
  10. [9]Halling C, Conroy S, Raymond T, et al. Use of Initial Endotracheal Versus Intravenous Epinephrine During Neonatal Cardiopulmonary Resuscitation in the Delivery Room: Review of a National Database J Pediatr, 2024.PMID 38631614
  11. [10]Vali P, Weiner GM, Sankaran D, Lakshminrusimha S What is the optimal initial dose of epinephrine during neonatal resuscitation in the delivery room? J Perinatol, 2021.PMID 33712718
  12. [11]Seidler AL, Aberoumand M, Hunter KE, et al. Deferred cord clamping, cord milking, and immediate cord clamping at preterm birth: a systematic review and individual participant data meta-analysis Lancet, 2023.PMID 37977169
  13. [12]Gomersall J, Berber S, Middleton P, et al. Umbilical Cord Management at Term and Late Preterm Birth: A Meta-analysis Pediatrics, 2021.PMID 33632933
  14. [13]Tarnow-Mordi W, Morris J, Kirby A, et al. Delayed versus Immediate Cord Clamping in Preterm Infants N Engl J Med, 2017.PMID 29081267
  15. [14]Jacobs SE, Berg M, Hunt R, et al. Cooling for newborns with hypoxic ischaemic encephalopathy Cochrane Database Syst Rev, 2013.PMID 23440789
  16. [15]Kirpalani H, Ratcliffe SJ, Keszler M, et al. Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants: The SAIL Randomized Clinical Trial JAMA, 2019.PMID 30912836
  17. [16]Halling C, Raymond T, Brown LS, et al. Neonatal delivery room CPR: An analysis of the Get with the Guidelines-Resuscitation Registry Resuscitation, 2021.PMID 33080368
  18. [17]Ramaswamy VV, Bandyopadhyay T, Nangia S, et al. Assessment of Change in Practice of Routine Tracheal Suctioning Approach of Non-Vigorous Infants Born through Meconium-Stained Amniotic Fluid: A Pragmatic Systematic Review and Meta-Analysis of Evidence outside Randomized Trials Neonatology, 2023.PMID 36754038
  19. [18]Binkhorst M, van Elsäcker E, Matthijsse RP, et al. Threshold to initiate chest compressions for bradycardia at birth: A narrative review J Perinatol, 2025.PMID 40360699
  20. [19]American College of Obstetricians and Gynecologists' Task Force on Neonatal Encephalopathy Executive summary: Neonatal encephalopathy and neurologic outcome, second edition Obstet Gynecol, 2014.PMID 24785633

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