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O&G TopicsGynaecological health — sexually transmitted infections

O&G · Gynaecological health — sexually transmitted infections

STI screening and management for the gynaecologist: the panel, the doses, and the partner notification framework (ASHM / CDC 2021)

Also known as STI screening · Sexually transmissible infection screening · Chlamydia treatment · Gonorrhoea treatment · Syphilis serology interpretation · Partner notification · Expedited partner therapy

Exam-exhaustive FRANZCOG fellowship topic on STI screening and management for the gynaecologist: the structured screening panel (chlamydia/gonorrhoea NAAT, syphilis serology, HIV, hepatitis B/C, HPV), the verbatim ASHM / CDC 2021 first-line drug/dose/duration for the common curable STIs (chlamydia doxycycline 100 mg BD for 7 days, gonorrhoea ceftriaxone 500 mg IMI plus azithromycin 1 g PO, trichomoniasis metronidazole 400 mg BD for 7 days, early syphilis benzathine benzylpenicillin 2.4 MU IMI), the partner notification and contact tracing framework including the ANZ Public Health Act legal duties, and the test-of-cure and retest-at-3-months policy. RANZCOG-primary and anchored to the ASHM Australian STI Management Guidelines with CDC 2021 deltas.

high18 referencesUpdated 27 July 202613 min readVerification in progress

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FRANZCOGMRCOGABOGFRCSCMRCPI

Red flags

  • Positive syphilis serology in pregnancy is a same-day urgent specialist referral — only penicillin treats the fetus, and late treatment causes congenital syphilis
  • Treat uncomplicated gonorrhoea with dual therapy in Australia (ceftriaxone plus azithromycin) — monotherapy risks resistance and falls outside the ASHM guideline
  • A pregnant woman with chlamydia is switched from doxycycline to azithromycin 1 g PO stat — doxycycline is contraindicated in pregnancy
  • Counsel every patient on metronidazole to avoid alcohol during and for 24 hours after treatment — the disulfiram reaction is unpleasant and avoidable
  • Ceftriaxone allergy, treatment failure or suspected cephalosporin-resistant gonorrhoea is a 24-hour public health notification and an infectious diseases consult
  • Any positive syphilis result in a child triggers an urgent specialist and child-protection discussion — congenital and vertical transmission is only one of the possibilities
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Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

FRANZCOGMRCOGABOGFRCSCMRCPI

Red flags

  • Positive syphilis serology in pregnancy is a same-day urgent specialist referral — only penicillin treats the fetus, and late treatment causes congenital syphilis
  • Treat uncomplicated gonorrhoea with dual therapy in Australia (ceftriaxone plus azithromycin) — monotherapy risks resistance and falls outside the ASHM guideline
  • A pregnant woman with chlamydia is switched from doxycycline to azithromycin 1 g PO stat — doxycycline is contraindicated in pregnancy
  • Counsel every patient on metronidazole to avoid alcohol during and for 24 hours after treatment — the disulfiram reaction is unpleasant and avoidable
  • Ceftriaxone allergy, treatment failure or suspected cephalosporin-resistant gonorrhoea is a 24-hour public health notification and an infectious diseases consult
  • Any positive syphilis result in a child triggers an urgent specialist and child-protection discussion — congenital and vertical transmission is only one of the possibilities
One-line fellowship answer

For every reproductive-age woman with a genital symptom — discharge, postcoital or intermenstrual bleeding, pelvic pain, ulcer, rash — and for every woman due for screening, run the structured STI panel: chlamydia and gonorrhoea NAAT (self-collected vaginal swab is the test of choice), syphilis serology, HIV, hepatitis B surface antigen and core antibody, hepatitis C antibody, and a cervical screen (HPV plus LBC) if due. Then treat the common curable STIs with the verbatim ANZ first-line doses: chlamydia doxycycline 100 mg PO twice daily for 7 days; gonorrhoea ceftriaxone 500 mg IMI plus azithromycin 1 g PO (dual therapy maintained in Australia); trichomoniasis metronidazole 400 mg PO twice daily for 7 days (or 2 g stat); early syphilis benzathine benzylpenicillin 2.4 MU IMI stat — doses per the ASHM Australian STI Management Guidelines.[1][15][16][17][18]

A 22-year-old woman walks into your gynaecology clinic with postcoital bleeding and a new partner. She is embarrassed, half-apologetic — "I'm sure it's nothing, doctor." Your job over the next twenty minutes is to take a sexual history without judgement, run the right panel, send the right swabs, treat what you find with the correct dose, and start a partner notification conversation that complies with the Public Health Act. STI screening is not an add-on to the gynaecology consult — it is the consult.[1][2][3]

Why this matters — the burden in Australia

highest of any notifiable diseaseChlamydia notificationsyoung people under 30 carry the burden
rising in women of reproductive ageGonorrhoea trenddual therapy still recommended in ANZ
re-emergingCongenital syphilisdrive syphilis screening in pregnancy
commonReinfection after chlamydiaretest at 3 months regardless of partner treatment
[1] [2]

Overview and definition

A sexually transmissible infection (STI) is any infection acquired through sexual contact — vaginal, anal or oral. The gynaecologist's job is to split them into bacterial and protozoal (curable) — chlamydia, gonorrhoea, syphilis, trichomoniasis, mycoplasma — and viral (incurable, modifiable) — HIV, hepatitis B, hepatitis C, HPV, HSV — because that split drives the consultation, the partner conversation and the follow-up plan.[1]

The Australian framework the gynaecologist anchors to is the ASHM Australian STI Management Guidelines for Use in Primary Care (endorsed by the Blood Borne Viruses and Sexually Transmitted Infections Standing Committee, funded by the Australian Centre for Disease Control).[1] The global comparator is the CDC Sexually Transmitted Infections Treatment Guidelines, 2021 (Workowski et al., MMWR 70(RR-4)).[1] Both are convergent on most points; they diverge on gonorrhoea dual therapy, where Australia maintains ceftriaxone plus azithromycin to slow resistance, while the 2021 CDC update moved to ceftriaxone monotherapy — covered in the regional deltas section.[1][6]

STI screening is opportunistic and risk-basedAnnual screening of all sexually active women aged under 25 is recommended in Australia and by the USPSTF, plus older women at increased risk (new partner, multiple partners, partner with an STI). Test anyone with a genital symptom, anyone requesting a check, and at every antenatal booking visit.[1][2]
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References18ShowHide
  1. [1]Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I, Reno H, Zenilman JM, Bolan GA Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep, 2021.PMID 34292926
  2. [2]Cantor A, Dana T, Griffin JC, Nelson HD, Weeks C Screening for Chlamydial and Gonococcal Infections: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA, 2021.PMID 34519797
  3. [3]Ferreira A, Young T, Mathews C, Zunza M, Low N Strategies for partner notification for sexually transmitted infections, including HIV. Cochrane Database Syst Rev, 2013.PMID 24092529
  4. [4]Chen LF, Wang TC, Chen FL, Hsu SC, Hsu CW Efficacy of doxycycline versus azithromycin for the treatment of rectal chlamydia: a systematic review and meta-analysis. J Antimicrob Chemother, 2021.PMID 34529798
  5. [5]Peuchant O, Lhomme E, Martinet P, Grob A, Baïta D Doxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled trial. Lancet Infect Dis, 2022.PMID 35550262
  6. [6]Quilter LAS, St Cyr SB, Barbee LA The Management of Gonorrhea in the Era of Emerging Antimicrobial Resistance: What Primary Care Clinicians Should Know. Med Clin North Am, 2024.PMID 38331480
  7. [7]Holderman JL, Thomas JC, Schlanger K, Black JM, Town K Sustained Transmission of Neisseria gonorrhoeae with High-Level Resistance to Azithromycin, in Indianapolis, Indiana, 2017-2018. Clin Infect Dis, 2021.PMID 34492693
  8. [8]Katz AR, Komeya AY, Kirkcaldy RD, Whelen AC, Soge OO Cluster of Neisseria gonorrhoeae Isolates With High-level Azithromycin Resistance and Decreased Ceftriaxone Susceptibility, Hawaii, 2016. Clin Infect Dis, 2017.PMID 28549097
  9. [9]American College of Obstetricians and Gynecologists ACOG Committee Opinion No. 651: Menstruation in Girls and Adolescents: Using the Menstrual Cycle as a Vital Sign. Obstet Gynecol, 2015.PMID 26595586
  10. [10]Bhatla N, Puri K, Joseph E, Kriplani A, Iyer VK, Sreenivas V Association of Chlamydia trachomatis infection with human papillomavirus (HPV) & cervical intraepithelial neoplasia - a pilot study. Indian J Med Res, 2013.PMID 23640561
  11. [11]Manning S Genital Complaints at the Extremes of Age. Emerg Med Clin North Am, 2019.PMID 30940366
  12. [12]Adams JA Understanding Medical Findings in Child Sexual Abuse: An Update For 2018. Acad Forensic Pathol, 2018.PMID 31240081
  13. [13]American College of Obstetricians and Gynecologists ACOG Committee Opinion No. 760: Dysmenorrhea and Endometriosis in the Adolescent. Obstet Gynecol, 2018.PMID 30461694
  14. [14]Westhoff CL, Jones HE, Guiahi M Do new guidelines and technology make the routine pelvic examination obsolete? J Womens Health (Larchmt), 2011.PMID 21194307
  15. [15]Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine Chlamydia — Australian STI Management Guidelines STI Guidelines Australia, 2025.Source
  16. [16]Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine Gonorrhoea — Australian STI Management Guidelines STI Guidelines Australia, 2025.Source
  17. [17]Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine Trichomoniasis — Australian STI Management Guidelines STI Guidelines Australia, 2025.Source
  18. [18]Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine Syphilis — Australian STI Management Guidelines STI Guidelines Australia, 2025.Source

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