O&G · Antenatal care — maternal medicine
Preeclampsia: diagnosis and management
Also known as Pre-eclampsia · Preeclampsia with severe features · Superimposed preeclampsia · Toxaemia of pregnancy · Severe preeclampsia
Exam-exhaustive FRANZCOG reference on diagnosing and managing preeclampsia — the ISSHP 2021 criteria with every threshold, ACOG PB 222 severe features, severe-range treatment inside 30 to 60 minutes with drug, dose and ceiling, the Zuspan magnesium regimen with monitoring and antidote, fluid restriction, angiogenic markers and fullPIERS, and timing of birth answered gestation by gestation with PHOENIX, HYPITAT and HYPITAT-II. SOMANZ 2023 and RANZCOG-anchored, globally tagged to MRCOG and ABOG.
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10 MCQs with explanations
Target exams
Red flags
Half an hour for the pressure. She is 34 weeks, 168/112 mmHg, a headache she describes as the worst she has had, and a platelet count of 88 x 10^9/L that came back while you were walking to see her. Treat severe-range pressure inside 30 to 60 minutes; the rest of the hour is seizure prophylaxis, fluid discipline, fetal assessment and birth planning.[3][1]
Overview and definition
Preeclampsia is a maternal multisystem syndrome of placental origin, not a blood pressure problem with proteinuria attached. Framing it that way is what lets you diagnose the woman whose dipstick is clean and whose platelets are falling.[1][17]
- Hypertension — systolic 140 mmHg or more and/or diastolic 90 mmHg or more, arising de novo at or after 20 weeks.[1][2]
- Plus at least one of: proteinuria, maternal organ dysfunction, or uteroplacental dysfunction.[1]
- Superimposed preeclampsia — any of those new features appearing at or after 20 weeks in a woman with pre-existing chronic hypertension.[1][3]
You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the Obstetrics & Gynaecology fellowship atlas.
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- [1]Magee LA, Brown MA, Hall DR, et al. The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice Pregnancy Hypertens, 2022.PMID 35066406
- [2]Shanmugalingam R, Barrett HL, Beech A, et al. A summary of the 2023 Society of Obstetric Medicine of Australia and New Zealand (SOMANZ) hypertension in pregnancy guideline Med J Aust, 2024.PMID 38763516
- [3]American College of Obstetricians and Gynecologists Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222 Obstet Gynecol, 2020.PMID 32443079
- [4]Chappell LC, Brocklehurst P, Green ME, et al. Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial Lancet, 2019.PMID 31472930
- [5]Koopmans CM, Bijlenga D, Groen H, et al. Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial Lancet, 2009.PMID 19656558
- [6]Broekhuijsen K, van Baaren GJ, van Pampus MG, et al. Immediate delivery versus expectant monitoring for hypertensive disorders of pregnancy between 34 and 37 weeks of gestation (HYPITAT-II): an open-label, randomised controlled trial Lancet, 2015.PMID 25817374
- [7]Beardmore-Gray A, Vousden N, Seed PT, et al. Planned delivery or expectant management for late preterm pre-eclampsia in low-income and middle-income countries (CRADLE-4): a multicentre, open-label, randomised controlled trial Lancet, 2023.PMID 37393919
- [8]Altman D, Carroli G, Duley L, et al. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial Lancet, 2002.PMID 12057549
- [9]Duley L, Gülmezoglu AM, Henderson-Smart DJ, Chou D Magnesium sulphate and other anticonvulsants for women with pre-eclampsia Cochrane Database Syst Rev, 2010.PMID 21069663
- [10]Duley L, Meher S, Jones L Drugs for treatment of very high blood pressure during pregnancy Cochrane Database Syst Rev, 2013.PMID 23900968
- [11]Easterling T, Mundle S, Bracken H, et al. Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial Lancet, 2019.PMID 31378394
- [12]Zeisler H, Llurba E, Chantraine F, et al. Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia N Engl J Med, 2016.PMID 26735990
- [13]Duhig KE, Myers J, Seed PT, et al. Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial Lancet, 2019.PMID 30948284
- [14]Hurrell A, Webster L, Sparkes J, et al. Repeat placental growth factor-based testing in women with suspected preterm pre-eclampsia (PARROT-2): a multicentre, parallel-group, superiority, randomised controlled trial Lancet, 2024.PMID 38342128
- [15]von Dadelszen P, Payne B, Li J, et al. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model Lancet, 2011.PMID 21185591
- [16]Roberts D, Brown J, Medley N, Dalziel SR Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth Cochrane Database Syst Rev, 2017.PMID 28321847
- [17]Rana S, Lemoine E, Granger JP, Karumanchi SA Preeclampsia: Pathophysiology, Challenges, and Perspectives Circ Res, 2019.PMID 30920918
- [18]Magee LA, Nicolaides KH, von Dadelszen P Preeclampsia N Engl J Med, 2022.PMID 35544388
- [19]Sibai BM Etiology and management of postpartum hypertension-preeclampsia Am J Obstet Gynecol, 2012.PMID 21963308
- [20]Bellamy L, Casas JP, Hingorani AD, Williams DJ Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis BMJ, 2007.PMID 17975258
- [21]Magee LA, von Dadelszen P, Rey E, et al. Less-tight versus tight control of hypertension in pregnancy. N Engl J Med, 2015.PMID 25629739
- [22]Rolnik DL, Wright D, Poon LC, et al. Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia. N Engl J Med, 2017.PMID 28657417