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O&G TopicsAntenatal care — preconception

O&G · Antenatal care — preconception

Pre-pregnancy counselling and optimisation

Also known as Preconception care · Pre-pregnancy counselling · Pre-pregnancy optimisation · Preconception counselling

Exam-exhaustive FRANZCOG fellowship reference on pre-pregnancy counselling and optimisation — folate dosing (400 micrograms vs 5 mg high-risk), iodine 150 micrograms, BMI and weight, the teratogen medication review, sodium valproate, diabetes HbA1c target below 6.5%, thyroid, epilepsy, carrier screening timing and interpregnancy interval. Anchored on RANZCOG C-Obs 3a v13.1 (November 2024), globally tagged to MRCOG and ABOG.

high14 referencesUpdated 26 July 202610 min readVerification in progress

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FRANZCOGMRCOGABOGFRCSCMRCPI

Red flags

  • A woman already pregnant at the first counselling visit — the neural tube closed four weeks ago and the glycaemic window has shut
  • A woman still on an ACE inhibitor, warfarin, sodium valproate, retinoid or methotrexate at conception
  • 400 micrograms of folate prescribed to a woman on antiepileptics, with previous neural tube defect, diabetes or BMI over 30 — she needs 5 mg
  • Pregestational diabetes with HbA1c above 6.5% at conception — congenital anomaly risk climbs steeply
  • Obesity with BMI over 40 not offered weight-reduction or bariatric-surgery discussion before conception
  • Sodium valproate continued in a woman who could fall pregnant — teratogenic AND neurodevelopmentally harmful
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Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

FRANZCOGMRCOGABOGFRCSCMRCPI

Red flags

  • A woman already pregnant at the first counselling visit — the neural tube closed four weeks ago and the glycaemic window has shut
  • A woman still on an ACE inhibitor, warfarin, sodium valproate, retinoid or methotrexate at conception
  • 400 micrograms of folate prescribed to a woman on antiepileptics, with previous neural tube defect, diabetes or BMI over 30 — she needs 5 mg
  • Pregestational diabetes with HbA1c above 6.5% at conception — congenital anomaly risk climbs steeply
  • Obesity with BMI over 40 not offered weight-reduction or bariatric-surgery discussion before conception
  • Sodium valproate continued in a woman who could fall pregnant — teratogenic AND neurodevelopmentally harmful
One-line fellowship answer

Pre-pregnancy counselling is the opportunistic optimisation of maternal health before conception so that pregnancy starts on folate 400 micrograms daily (5 mg high-risk), iodine 150 micrograms, a reviewed medication list free of teratogens, an HbA1c below 6.5% for diabetes, a BMI under 30, and no alcohol or tobacco. The aim is a planned pregnancy on optimised chronic disease control — because the neural tube and the fetal heart form before most women know they are pregnant.[1][2]

It is a Tuesday in the pre-pregnancy clinic. A 34-year-old with type 1 diabetes, on an ACE inhibitor, taking 400 micrograms of folate, asks whether she can start trying next month. Every one of those facts is a problem the counselling visit exists to fix — and if the visit happens after conception, three of them are already too late. Pre-pregnancy care is the one part of obstetrics where the registrar's job is to prevent the pathology rather than manage it.[1][5]

Overview and definition

Pre-pregnancy (preconception) counselling is the assessment and optimisation of a woman's health, lifestyle, medications and chronic disease before she conceives, with the explicit aim of reducing maternal and fetal harm. RANZCOG frames it as advice to "support the counselling of women prior to pregnancy." It runs on two tracks at once.[1]

  • Universal (everyone): folate, iodine, no alcohol, no smoking, weight, immunisations, infection screening.[1][4]
  • Targeted (the at-risk woman): diabetes, hypertension and cardiac disease, epilepsy, thyroid disease, obesity, renal disease, thrombophilia, prior adverse outcome, consanguinity.[1][5]

The driver underneath all of it is one uncomfortable number: in the US, around two-thirds of reproductive-aged women carry at least one modifiable risk factor for an adverse pregnancy outcome. That is why preconception care is delivered opportunistically — at contraception review, the six-week postnatal visit, and any well-woman contact — not only at a dedicated clinic.[2]

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References14ShowHide
  1. [1]Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) Pre-pregnancy counselling (C-Obs 3a), Version 13.1 RANZCOG Clinical Guideline, 2024.Source
  2. [2]Cooper KM, Szymanski LM, David PS, et al. Prepregnancy Care and Counseling: A Review JAMA, 2026.PMID 42008245
  3. [3]MRC Vitamin Study Research Group Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group Lancet, 1991.PMID 1677062
  4. [4]Barry MJ, Nicholson WK, Silverstein M, et al. Folic Acid Supplementation to Prevent Neural Tube Defects: US Preventive Services Task Force Reaffirmation Recommendation Statement JAMA, 2023.PMID 37526713
  5. [5]American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics ACOG Practice Bulletin No. 201: Pregestational Diabetes Mellitus Obstet Gynecol, 2018.PMID 30461693
  6. [6]Meador KJ, Baker GA, Browning N, et al. Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years Neurology, 2012.PMID 22491865
  7. [7]Christensen J, Grønborg TK, Sørensen MJ, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism JAMA, 2013.PMID 23613074
  8. [8]Adam MP, Polifka JE, Friedman JM Evolving knowledge of the teratogenicity of medications in human pregnancy Am J Med Genet C Semin Med Genet, 2011.PMID 21766440
  9. [9]Murphy HR, Howgate C, O'Keefe J, et al. Characteristics and outcomes of pregnant women with type 1 or type 2 diabetes: a 5-year national population-based cohort study Lancet Diabetes Endocrinol, 2021.PMID 33516295
  10. [10]Tsiapakidou S, Mahmood T, Savona-Ventura C The potential impact of tobacco use on female fertility and pregnancy outcomes: An invited scientific review by EBCOG Eur J Obstet Gynecol Reprod Biol, 2023.PMID 37741060
  11. [11]Taylor PN, Okosieme OE, Dayan CM, et al. Therapy of endocrine disease: Impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis Eur J Endocrinol, 2014.PMID 24088547
  12. [12]Korevaar TIM, Leung AM, Alexander EK, et al. American Thyroid Association 2026 Guidelines for Thyroid Disease in Preconception, Pregnancy, and Postpartum Thyroid, 2026.PMID 42219800
  13. [13]Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) Reproductive Carrier Screening (C-Obs 63), Interim RANZCOG Statement, 2024.Source
  14. [14]Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) Substance use in pregnancy (C-Obs 53) RANZCOG Clinical Guideline, 2024.Source

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