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O&G TopicsAntenatal care — fetal growth and surveillance

O&G · Antenatal care — fetal growth and surveillance

Fetal growth restriction and small for gestational age

Also known as FGR · IUGR · Small for gestational age · SGA · Placental insufficiency · Intrauterine growth restriction

Exam-exhaustive FRANZCOG fellowship reference on fetal growth restriction and small for gestational age — the Delphi consensus definition (early and late FGR), customised versus INTERGROWTH standards, the differential of causes, surveillance with umbilical artery Doppler and cerebroplacental ratio, timing of delivery from TRUFFLE, GRIT and DIGITAT, the Alfirevic Cochrane evidence, and the Safer Baby Bundle. ANZ-primary, globally tagged.

high14 referencesUpdated 26 July 202611 min readVerification in progress

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Target exams

FRANZCOGMRCOGABOGFRCSCMRCPI

Red flags

  • An estimated fetal weight under the 3rd centile is fetal growth restriction until proven otherwise — not a constitutionally small fetus
  • Absent or reversed end-diastolic flow in the umbilical artery is a high-risk finding mandating admission and delivery planning, not outpatient surveillance
  • A normal Doppler today does not exclude deterioration before the next scan — the surveillance interval is part of the prescription
  • Customised and population standards label different women small — switching standards mid-pregnancy is a recognised source of error
  • Reduced fetal movements in a growth-restricted fetus may be the first sign of decompensation — never dismiss
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Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

FRANZCOGMRCOGABOGFRCSCMRCPI

Red flags

  • An estimated fetal weight under the 3rd centile is fetal growth restriction until proven otherwise — not a constitutionally small fetus
  • Absent or reversed end-diastolic flow in the umbilical artery is a high-risk finding mandating admission and delivery planning, not outpatient surveillance
  • A normal Doppler today does not exclude deterioration before the next scan — the surveillance interval is part of the prescription
  • Customised and population standards label different women small — switching standards mid-pregnancy is a recognised source of error
  • Reduced fetal movements in a growth-restricted fetus may be the first sign of decompensation — never dismiss
One-line fellowship answer

Fetal growth restriction is the failure of a fetus to reach its growth potential, and you define it with the Gordijn Delphi consensus: early FGR (under 32 weeks) needs an AC or EFW under the 3rd centile or absent end-diastolic flow (or AC/EFW under 10th centile with a raised UA or uterine artery PI); late FGR (32 weeks and over) needs an AC or EFW under the 3rd centile (or under 10th with crossing centiles or a low cerebroplacental ratio). Surveillance is umbilical artery Doppler-centred, timing of delivery is guided by TRUFFLE in early FGR and DIGITAT at term, and aspirin is prophylaxis — there is no in-utero cure.[1][2][4]

A 28-year-old woman is referred at 29 weeks with an estimated fetal weight on the 3rd centile and an umbilical artery pulsatility index above the 95th. The growth scan has just handed you the single most preventable cause of stillbirth, and what you do next — the surveillance interval, the Doppler interpretation, the timing of delivery — is the difference between a healthy baby and a perinatal mortality meeting. Fetal growth restriction is one of the highest-yield topics in the fellowship exam because it joins ultrasound, Doppler physiology, three landmark trials and a judgement about timing into one station. [1]

Overview and definition

The first distinction the examiner wants is between small for gestational age (SGA) and fetal growth restriction (FGR). They are not the same thing. [1]

  • SGA is a size: a birthweight or estimated fetal weight below the 10th centile for gestation. Many SGA babies are constitutionally small and healthy. [1]
  • FGR is a pathology: the failure of a fetus to reach its growth potential because of an underlying cause (usually placental insufficiency). An FGR fetus is at increased risk of stillbirth, neonatal morbidity and long-term impairment.

The Gordijn 2016 Delphi consensus resolved the historical confusion between the two by giving you reproducible criteria for early and late FGR — and these are the definitions to hold cold.[1]

The Delphi definitions
"Early (under 32): three solitary, four contributory. Late (32 and over): two solitary, four contributory." The solitary parameters diagnose FGR on their own; the contributory ones need a partner. Recite the centiles — under the 3rd is solitary, under the 10th needs a Doppler friend.[1]
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References14ShowHide
  1. [1]Gordijn SJ, Beune IM, Thilaganathan B, et al. Consensus definition of fetal growth restriction: a Delphi procedure Ultrasound Obstet Gynecol, 2016.PMID 26909664
  2. [2]Lees C, Marlow N, Arabin B, et al. Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the TRUFFLE trial Ultrasound Obstet Gynecol, 2013.PMID 24078432
  3. [3]Thornton JG, Hornbuckle J, Vail A, et al. Infant wellbeing at 2 years of age in the Growth Restriction Intervention Trial (GRIT) Lancet, 2004.PMID 15302194
  4. [4]Boers KE, Vijgen SM, Bijlenga D, et al. Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT) BMJ, 2010.PMID 21177352
  5. [5]Alfirevic Z, Stampalija T, Dowswell T Fetal and umbilical Doppler ultrasound in high-risk pregnancies Cochrane Database Syst Rev, 2017.PMID 28613398
  6. [6]Papageorghiou AT, Ohuma EO, Altman DG, et al. International standards for fetal growth based on serial ultrasound measurements: the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project Lancet, 2014.PMID 25209488
  7. [7]American College of Obstetricians and Gynecologists Fetal Growth Restriction: ACOG Practice Bulletin, Number 227 Obstet Gynecol, 2021.PMID 33481528
  8. [8]Clausson B, Gardosi J, Francis A, et al. Perinatal outcome in SGA births defined by customised versus population-based birthweight standards BJOG, 2001.PMID 11510708
  9. [9]Roberge S, Bujold E, Nicolaides KH Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis Am J Obstet Gynecol, 2018.PMID 29138036
  10. [10]Lees CC, Marlow N, Van Wassenaer-Leemhuis A, et al. 2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE) Lancet, 2015.PMID 25747582
  11. [11]Baschat AA, Galan HL, Lee W, et al. The role of the fetal biophysical profile in the management of fetal growth restriction Am J Obstet Gynecol, 2022.PMID 35369904
  12. [12]Ganzevoort W, Thornton JG, Marlow N, et al. Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials Ultrasound Obstet Gynecol, 2020.PMID 31125465
  13. [13]Alfirevic Z, Stampalija T, Dowswell T Fetal and umbilical Doppler ultrasound in high-risk pregnancies Cochrane Database Syst Rev, 2017.PMID 28613398
  14. [14]Gordijn SJ, Beune IM, Thilaganathan B, et al. Consensus definition of fetal growth restriction: a Delphi procedure Ultrasound Obstet Gynecol, 2016.PMID 26909664

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