ICU Vivas · Applied pharmacology
Clinical viva — your approach to antibiotic dosing in the critically ill
A clinical viva on antibiotic dosing in critical illness — loading for the enlarged volume, extended infusion for time-dependent kill, AUC-guided vancomycin, Hartford once-daily aminoglycosides, and up-titration for augmented renal clearance.
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CICMFFICMEDIC
Prompt
A clinical viva on antibiotic dosing in critical illness — loading for the enlarged volume, extended infusion for time-dependent kill, AUC-guided vancomycin, Hartford once-daily aminoglycosides, and up-titration for augmented renal clearance.
The question
"Take me through your approach to antibiotic dosing in a critically ill septic patient."[2]
References4ShowHide
- [1]Rybak MJ, Le J, et al. Executive Summary: Therapeutic Monitoring of Vancomycin for Serious Methicillin-Resistant Staphylococcus aureus Infections Pharmacotherapy, 2020.PMID 32227354
- [2]Roberts JA, Paul SK, et al. DALI: defining antibiotic levels in intensive care unit patients Clin Infect Dis, 2014.PMID 24429437
- [3]Bilbao-Meseguer I, Rodriguez-Gascon A, et al. Augmented Renal Clearance in Critically Ill Patients: A Systematic Review Clin Pharmacokinet, 2018.PMID 29441476
- [4]Nicolau DP, Freeman CD, et al. Experience with a once-daily aminoglycoside program administered to 2,184 adult patients Antimicrob Agents Chemother, 1995.PMID 7793867