ICU Vivas · Antimicrobial therapy
Data viva — the vancomycin AUC and the trough
A data viva on the vancomycin TDM — the trough, the AUC, the target (400-600), the renal function, and the dose adjustment.
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Prompt
A vancomycin trough and the AUC data from a septic patient, to be interpreted and the dose adjusted.
Stimulus
You are shown the vancomycin data from a 70-year-old with the MRSA bacteraemia:
| Parameter | Value |
|---|---|
| Dose | 1 g IV BID |
| Trough (day 3) | 8 mg/L |
| AUC24 (Bayesian) | 280 mg*h/L |
| CrCl | 85 mL/min |
| Weight | 80 kg |
Interpret and adjust.[1]
References1ShowHide
- [1]Bersten AD, Soni N (eds) Oh's Intensive Care Manual. 8th edition, Elsevier, 2018.