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ICU SAQsToxicology

ICU SAQs · Toxicology

Paracetamol overdose — the assessment and the management

A CICM Second-Part SAQ on the paracetamol overdose — the nomogram, the NAC regimen, the anaphylactoid reactions, the King's College criteria.

10 marks10 min2 min readSource-verified ·

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Prompt
A patient presents 6 hours after a single 20 g paracetamol ingestion. Outline your assessment and the management.

Question

[4]

A patient presents 6 hours after a single 20 g paracetamol ingestion. Outline your assessment and the management.

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References3ShowHide
  1. [1]Dart RC, Mullins ME, Matoushek T, et al. Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement. JAMA Network Open, 2023.PMID 37552484
  2. [2]Yarema M, et al. Anaphylactoid Reactions to Intravenous N-Acetylcysteine. Journal of Medical Toxicology, 2018.PMID 29423816
  3. [4]Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985) N Engl J Med, 1988.PMID 3059186
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