ICU SAQs · Pharmacology / toxicology
Antidotes in common ICU overdose
A CICM First Part SAQ - naloxone, N-acetylcysteine, atropine+pralidoxime, sodium bicarbonate, and digoxin Fab: mechanism, indication, and the key cautions (flumazenil seizures, NAC anaphylactoid).
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Prompt
Outline the antidotes used in the ICU for opioid, paracetamol, organophosphate, TCA, and digoxin poisoning, including their mechanism and cautions.
Question
Outline the antidotes used in the ICU for opioid, paracetamol, organophosphate, TCA, and digoxin poisoning, including their mechanism and cautions. [1] [2] [5]
References5ShowHide
- [1]Saari TI, Strang J, Dale O, et al. Clinical Pharmacokinetics and Pharmacodynamics of Naloxone Clin Pharmacokinet, 2024.PMID 38485851
- [2]Chiew AL, Reith D, Pomerleau A, et al. Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand Med J Aust, 2020.PMID 31786822
- [3]Eddleston M, Buckley NA, Eyer P, Dawson AH Management of acute organophosphorus pesticide poisoning Lancet, 2008.PMID 17706760
- [4]Pai K, Buckley NA, Isoardi KZ, et al. Optimising alkalinisation and its effect on QRS narrowing in tricyclic antidepressant poisoning Br J Clin Pharmacol, 2022.PMID 34312917
- [5]Chan BS, Buckley NA Digoxin-specific antibody fragments in the treatment of digoxin toxicity Clin Toxicol (Phila), 2014.PMID 25089630