ICU SAQs · Resuscitation
Antibiotics and source control in septic shock
A Second-Part question on the two definitive therapies for sepsis — antibiotics and source control — covering the time-to-antibiotic evidence, empirical choice and narrowing, and the physical removal of the infective focus.
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Prompt
Outline the principles governing antibiotic timing, choice and de-escalation, and the role of source control, in a patient with septic shock.
Question
Outline the principles governing antibiotic timing, choice and de-escalation, and the role of source control, in a patient with septic shock.
References2ShowHide
- [1]Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Intensive Care Medicine, 2021.PMID 34599691
- [2]Seymour CW, Gesten F, Prescott HC, et al. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. New England Journal of Medicine, 2017.PMID 28528569