ICU SAQs · Basic sciences
Determinants of oxygen delivery and systemic vascular resistance
A First-Part basic-science question on the circulatory and haematological determinants of oxygen delivery and afterload, framed around why septic shock is a high-output, low-SVR, utilisation-defect state rather than a delivery-defect state.
On this page
Study tools
Target exams
CICMFFICMEDIC
Prompt
State the determinants of systemic oxygen delivery (DO2) and of systemic vascular resistance (SVR), and explain how each is disturbed in septic shock.
Question
State the determinants of systemic oxygen delivery (DO₂) and of systemic vascular resistance (SVR), and explain how each is disturbed in septic shock.
References4ShowHide
- [1]Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 2016.PMID 26903338
- [2]Brealey D, Brand M, Hargreaves I, et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet, 2002.PMID 12133657
- [3]Rizvi A, et al. Hemoglobin Is a Vital Determinant of Arterial Oxygen Content in Hypoxemic Patients. Annals of the American Thoracic Society, 2017.PMID 28267932
- [4]Bersten AD, Soni N (eds) Oh's Intensive Care Manual. 8th edition, Elsevier, 2018.