Gen Surg Vivas · vascular
66-year-old infected ischaemic foot at WIfI 3 — infection-first sequencing, quartile counselling, and level selection
Fellowship viva on the infected ischaemic diabetic foot: infection-control-before-revascularisation sequencing, WIfI benefit-quartile counselling with BASIL-2 and BEST-CLI-diabetes numbers, duration-ladder antibiotics, and partial-foot amputation honesty.
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Examiner notes
Probe four domains: (1) SINBAD description in words with the IWGDF no-individual-prediction rule[14]; (2) infection control before revascularisation with the 59.54% minor-amputation-first figure and the duration ladder[13][36]; (3) WIfI benefit-quartile counselling with Q4 25.7% honesty plus BASIL-2/BEST-CLI numbers[12][44][45]; (4) level selection counselled-not-dictated with transmetatarsal and partial-foot pricing[50][54]. Award marks for exact numbers with named papers; deduct for quoting classification totals as prognoses, promising salvage in Q4, defaulting to 12-week antibiotics, or calling transmetatarsal definitive.
Model dialogue
Describe this ulcer so another clinician sees it. SINBAD in words — site, ischaemia, neuropathy, bacterial infection, area, depth — because the IWGDF makes SINBAD the first communication option with variables described rather than totalled, and recommends no system for predicting this specific ulcer's outcome.[14][7]
What comes first — vessels or infection? Infection control: nearly 60% of admitted infected feet need minor amputation to control infection before revascularisation, and PAD with WIfI benefit-stage-3 (RR 4.56) or high Wagner scores (RR 9.46) multiplies amputation risk — so debride and drain first, revascularise second.[13] Confirm bone first by probe-plus-X-ray (0.97/0.92 sequential, LR 12.8/0.02) with biopsy as gold, since MRI goes unconfirmed in 29.3%.[32][28][35]
What does WIfI 3 mean for his leg? Stage 3 concentrates with stage 4 for amputations, falling amputation-free survival and slower healing — yet stage-3 revascularisation accelerates healing, and benefit quartiles separate Q1 7.2% from Q4 25.7% one-year amputation at hazard 4.26 with over half amputated despite patent wires — so quote the quartile, and note the multidisciplinary 5.7% stage-4 figure as what a team can achieve.[9][12][10]
Which revascularisation, and what do the trials say for diabetes? PLAN first — patient risk, limb severity, anatomic complexity with GLASS and vein availability — then BASIL-2 infrapopliteal numbers favouring endovascular-first (HR 1.35 against vein-first, £1690 saved) and BEST-CLI-diabetes pricing late presentation (WIfI 3–4 in 73.7 vs 45.9%) with amputation 1.75-fold and death 1.63-fold independent — plus the 5-year split of death lower after bypass regardless of diabetes with amputation modality-blind but doubled by diabetes itself.[43][44][45][47]
How long are antibiotics, and does he need bone surgery? The tested floors as study regimens: 6 weeks where non-surgical treatment is chosen (65% remission, fewer gut events), 3 weeks after debridement (84 vs 73%, noninferior), 10 days for soft tissue (77 vs 71%) — with the 23-versus-16% new-osteomyelitis tail disclosed.[36][37][38] Operate for life-threat, limb-threat or failure (23% in the non-surgical series) with foot-sparing priority — conservative surgery succeeds in 49.1%, S. aureus leads at 51.3% — and complete resection shortens antibiotics without changing 12-month outcomes.[39][40][41]
If amputation is needed, what do you promise? Nothing dictated: deep infection with pulses favours below-ankle healing yet nothing alone excludes it; minor amputations heal below-ankle in 64% overall and 79% of survivors; transmetatarsal carries 30.16% pooled major-amputation risk and the all-partial-foot meta-analysis 23% with re-ulceration to 69% — so consent the ladder, the 26-week median healing, and lifelong surveillance for the 22.1%-per-year recurrence.[53][52][50][54][4]
References24ShowHide
- [14]Monteiro-Soares M, et al. Guidelines on the classification of foot ulcers in people with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev, 2024.PMID 37179483
- [7]Brocklehurst JD The Validity and Reliability of the SINBAD Classification System for Diabetic Foot Ulcers. Adv Skin Wound Care, 2023.PMID 37861669
- [13]Benyakorn T, et al. Association Between the Society for Vascular Surgery (SVS)-WIfI (Wound, Ischemia, Foot Infection) Classification, Wagner-Meggitt Classification, and Amputation Rate in Patients With Diabetic Foot Infection. Int J Low Extrem Wounds, 2024.PMID 37853714
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- [35]La Fontaine J, et al. Magnetic Resonance Imaging of Diabetic Foot Osteomyelitis: Imaging Accuracy in Biopsy-Proven Disease. J Foot Ankle Surg, 2021.PMID 33214100
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- [12]Hicks CW, et al. Evaluation of revascularization benefit quartiles using the Wound, Ischemia, and foot Infection classification system for diabetic patients with chronic limb-threatening ischemia. J Vasc Surg, 2021.PMID 33813024
- [10]Mathioudakis N, et al. The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system predicts wound healing but not major amputation in patients with diabetic foot ulcers treated in a multidisciplinary setting. J Vasc Surg, 2017.PMID 28274750
- [43]Conte MS, et al. Global vascular guidelines on the management of chronic limb-threatening ischemia. J Vasc Surg, 2019.PMID 31159978
- [44]Moakes CA, et al. Vein bypass first vs. best endovascular treatment first revascularisation strategy for chronic limb-threatening ischaemia due to infra-popliteal disease: the BASIL-2 RCT. Health Technol Assess, 2024.PMID 39397484
- [45]Ochoa Chaar CI, et al. The impact of diabetes mellitus on the outcomes of revascularization for chronic limb-threatening ischemia in the BEST-CLI trial. J Vasc Surg, 2025.PMID 39332785
- [47]Callegari S, et al. Diabetes status and long-term mortality and major amputation outcomes following revascularization in chronic limb-threatening ischemia. J Vasc Surg, 2025.PMID 40348290
- [36]Tone A, et al. Six-week versus twelve-week antibiotic therapy for nonsurgically treated diabetic foot osteomyelitis: a multicenter open-label controlled randomized study. Diabetes Care, 2015.PMID 25414157
- [37]Gariani K, et al. Three Weeks Versus Six Weeks of Antibiotic Therapy for Diabetic Foot Osteomyelitis: A Prospective, Randomized, Noninferiority Pilot Trial. Clin Infect Dis, 2021.PMID 33242083
- [38]Pham TT, et al. Moderate to Severe Soft Tissue Diabetic Foot Infections: A Randomized, Controlled, Pilot Trial of Post-debridement Antibiotic Treatment for 10 versus 20 days. Ann Surg, 2022.PMID 35623048
- [39]Game FL, et al. Primarily non-surgical management of osteomyelitis of the foot in diabetes. Diabetologia, 2008.PMID 18385975
- [40]Aragón-Sánchez FJ, et al. Outcomes of surgical treatment of diabetic foot osteomyelitis: a series of 185 patients with histopathological confirmation of bone involvement. Diabetologia, 2008.PMID 18719880
- [41]Lavery LA, et al. Does complete resection of infected bone improve clinical outcomes in patients with diabetic foot osteomyelitis? Int Wound J, 2024.PMID 39375181
- [53]Larsson J, et al. Local signs and symptoms in relation to final amputation level in diabetic patients. A prospective study of 187 patients with foot ulcers. Acta Orthop Scand, 1994.PMID 7976281
- [52]Svensson H, et al. Minor amputation in patients with diabetes mellitus and severe foot ulcers achieves good outcomes. J Wound Care, 2011.PMID 21727875
- [50]Thorud JC, et al. Reoperation and Reamputation After Transmetatarsal Amputation: A Systematic Review and Meta-Analysis. J Foot Ankle Surg, 2016.PMID 27475711
- [54]Greenfield SH, et al. A systematic review and meta-analysis on partial foot amputation in diabetic foot ulcers. J Vasc Surg, 2026.PMID 41232818
- [4]Fu XL, et al. Global recurrence rates in diabetic foot ulcers: A systematic review and meta-analysis. Diabetes Metab Res Rev, 2019.PMID 30916434